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Transient facial nerve paralysis (Bell's palsy) following intranasal delivery of a genetically detoxified mutant of Escherichia coli heat labile toxin.

Lewis, DJ, Huo, Z, Barnett, S, Kromann, I, Giemza, R, Galiza, E, Woodrow, M, Thierry-Carstensen, B, Andersen, P and Novicki, D (2009) Transient facial nerve paralysis (Bell's palsy) following intranasal delivery of a genetically detoxified mutant of Escherichia coli heat labile toxin. PLoS One, 4 (9).

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Abstract

An association was previously established between facial nerve paralysis (Bell's palsy) and intranasal administration of an inactivated influenza virosome vaccine containing an enzymatically active Escherichia coli Heat Labile Toxin (LT) adjuvant. The individual component(s) responsible for paralysis were not identified, and the vaccine was withdrawn.

Item Type: Article
Authors :
NameEmailORCID
Lewis, DJd.j.lewis@surrey.ac.ukUNSPECIFIED
Huo, Zz.huo@surrey.ac.ukUNSPECIFIED
Barnett, SUNSPECIFIEDUNSPECIFIED
Kromann, IUNSPECIFIEDUNSPECIFIED
Giemza, RUNSPECIFIEDUNSPECIFIED
Galiza, EUNSPECIFIEDUNSPECIFIED
Woodrow, MUNSPECIFIEDUNSPECIFIED
Thierry-Carstensen, BUNSPECIFIEDUNSPECIFIED
Andersen, PUNSPECIFIEDUNSPECIFIED
Novicki, DUNSPECIFIEDUNSPECIFIED
Date : 2009
Identification Number : 10.1371/journal.pone.0006999
Uncontrolled Keywords : AIDS Vaccines, Adult, Axons, Bacterial Toxins, Bell Palsy, Enterotoxins, Escherichia coli, Escherichia coli Proteins, Female, Gangliosides, Humans, Inflammation, Male, Mutation, Protein Binding, Tuberculosis Vaccines, Vaccines, Inactivated
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:13
Last Modified : 17 May 2017 14:40
URI: http://epubs.surrey.ac.uk/id/eprint/822799

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