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Overexpression of heat-shock proteins reduces survival of Mycobacterium tuberculosis in the chronic phase of infection.

Stewart, GR, Snewin, VA, Walzl, G, Hussell, T, Tormay, P, O'Gaora, P, Goyal, M, Betts, J, Brown, IN and Young, DB (2001) Overexpression of heat-shock proteins reduces survival of Mycobacterium tuberculosis in the chronic phase of infection. Nat Med, 7 (6). pp. 732-737.

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Abstract

Elevated expression of heat-shock proteins (HSPs) can benefit a microbial pathogen struggling to penetrate host defenses during infection, but at the same time might provide a crucial signal alerting the host immune system to its presence. To determine which of these effects predominate, we constructed a mutant strain of Mycobacterium tuberculosis that constitutively overexpresses Hsp70 proteins. Although the mutant was fully virulent in the initial stage of infection, it was significantly impaired in its ability to persist during the subsequent chronic phase. Induction of microbial genes encoding HSPs might provide a novel strategy to boost the immune response of individuals with latent tuberculosis infection.

Item Type: Article
Authors :
NameEmailORCID
Stewart, GRg.stewart@surrey.ac.ukUNSPECIFIED
Snewin, VAUNSPECIFIEDUNSPECIFIED
Walzl, GUNSPECIFIEDUNSPECIFIED
Hussell, TUNSPECIFIEDUNSPECIFIED
Tormay, PUNSPECIFIEDUNSPECIFIED
O'Gaora, PUNSPECIFIEDUNSPECIFIED
Goyal, MUNSPECIFIEDUNSPECIFIED
Betts, JUNSPECIFIEDUNSPECIFIED
Brown, INUNSPECIFIEDUNSPECIFIED
Young, DBUNSPECIFIEDUNSPECIFIED
Date : June 2001
Identification Number : 10.1038/89113
Uncontrolled Keywords : Animals, Bacterial Proteins, Electrophoresis, Polyacrylamide Gel, Gene Expression, HSP70 Heat-Shock Proteins, Heat-Shock Proteins, Humans, Interferon-gamma, Lung, Macrophages, Mice, Mice, Inbred C57BL, Mutation, Mycobacterium bovis, Mycobacterium tuberculosis, Repressor Proteins, Spleen, Temperature, Tuberculosis
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:12
Last Modified : 17 May 2017 14:40
URI: http://epubs.surrey.ac.uk/id/eprint/822730

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