Invited review: Integration of human sleep-wake regulation and circadian rhythmicity

Dijk, DJ and Lockley, SW (2002) Invited review: Integration of human sleep-wake regulation and circadian rhythmicity Journal of Applied Physiology, 92 (2). pp. 852-862.

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Abstract

The human sleep-wake cycle is generated by a circadian process, originating from the suprachiasmatic nuclei, in interaction with a separate oscillatory process: the sleep homeostat. The sleep-wake cycle is normally timed to occur at a specific phase relative to the external cycle of light-dark exposure. It is also timed at a specific phase relative to interal circadian rhythms, such as the pineal melatonin rhythm, the circadian sleep-wake propensity rhythm, and the rhythm of responsiveness of the circadian pacemaker to light. Variations in these internal and external phase relationships, such as those that occur in blindness, aging, morning and evening, and advanced and delayed sleep-phase syndrome, lead to sleep disruptions and complaints. Changes in ocular circadian photoreception, interindividual variation in the near-24-h intrinsic period of the circadian pacemaker, and sleep homeostasis can contribute to variations in external and internal phase. Recent findings on the physiological and molecular-genetic correlates of circadian sleep disorders suggest that the timing of the sleep-wake cycle and circadian rhythms is closely integrated but is, in part, regulated differentially.

Item Type:	Article
Authors :	Name Email ORCID Dijk, DJ d.j.dijk@surrey.ac.uk UNSPECIFIED Lockley, SW UNSPECIFIED UNSPECIFIED
Date :	3 July 2002
Depositing User :	Symplectic Elements
Date Deposited :	17 May 2017 09:12
Last Modified :	17 May 2017 14:40
URI:	http://epubs.surrey.ac.uk/id/eprint/822726

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