University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Psychological impact of genetic testing for familial hypercholesterolemia within a previously aware population: A randomized controlled trial

Marteau, T, Senior, V, Humphries, SE, Bobrow, M, Cranston, T, Crook, MA, Day, L, Fernandez, M, Horne, R, Iversen, A , Jackson, Z, Lynas, J, Middleton-Price, H, Savine, R, Sikorski, J, Watson, M, Weinman, J, Wierzbicki, AS and Wray, R (2004) Psychological impact of genetic testing for familial hypercholesterolemia within a previously aware population: A randomized controlled trial American Journal of Medical Genetics Part A, 128A (3). pp. 285-293.

Full text not available from this repository.

Abstract

This trial tests the hypothesis that confirming a clinical diagnosis of familial hypercholesterolemia (FH) by finding a genetic mutation reduces patients' perceptions of control over the disease and adherence to risk-reducing behaviors. Three hundred forty-one families, comprising 341 hypercholesterolemia probands and 128 adult relatives, were randomized to one of two groups: (a) routine clinical diagnosis; (b) routine clinical diagnosis plus genetic testing (mutation searching in probands and direct gene testing in relatives). The main outcome measures were perceptions of control over hypercholesterolemia, adherence to cholesterol-lowering medication, diet, physical activity, and smoking. There was no support for the main hypothesis: finding a mutation had no impact on perceived control or adherence to risk-reducing behavior (all P-values > 0.10). While all groups believed that lowering cholesterol was an effective way of reducing the risk of a heart attack, participants in whom a mutation was found believed less strongly in the efficacy of diet in reducing their cholesterol level (P = 0.02 at 6 months) and showed a trend in believing more strongly in the efficacy of cholesterol-lowering medication (P = 0.06 at 6 months). In conclusion, finding a mutation to confirm a clinical diagnosis of FH in a previously aware population does not reduce perceptions of control or adherence to risk-reducing behaviors. The pattern of findings leads to the new hypothesis that genetic testing does not affect the extent to which people feel they have control over a condition, but does affect their perceptions of how control is most effectively achieved. Further work is needed to determine whether similar results will be obtained in populations with little previous awareness of their risks. (C) 2004 Wiley-Liss, Inc.

Item Type: Article
Authors :
NameEmailORCID
Marteau, TUNSPECIFIEDUNSPECIFIED
Senior, Vv.senior@surrey.ac.ukUNSPECIFIED
Humphries, SEUNSPECIFIEDUNSPECIFIED
Bobrow, MUNSPECIFIEDUNSPECIFIED
Cranston, TUNSPECIFIEDUNSPECIFIED
Crook, MAUNSPECIFIEDUNSPECIFIED
Day, LUNSPECIFIEDUNSPECIFIED
Fernandez, MUNSPECIFIEDUNSPECIFIED
Horne, RUNSPECIFIEDUNSPECIFIED
Iversen, AUNSPECIFIEDUNSPECIFIED
Jackson, ZUNSPECIFIEDUNSPECIFIED
Lynas, JUNSPECIFIEDUNSPECIFIED
Middleton-Price, HUNSPECIFIEDUNSPECIFIED
Savine, RUNSPECIFIEDUNSPECIFIED
Sikorski, JUNSPECIFIEDUNSPECIFIED
Watson, MUNSPECIFIEDUNSPECIFIED
Weinman, JUNSPECIFIEDUNSPECIFIED
Wierzbicki, ASUNSPECIFIEDUNSPECIFIED
Wray, RUNSPECIFIEDUNSPECIFIED
Date : 2004
Identification Number : 10.1002/ajmg.a.30102
Uncontrolled Keywords : genetic testing psychological consequences familial hypercholesterolemia health behavior perceived control illness perceptions HEART-DISEASE BEHAVIOR-CHANGE PRIMARY-CARE RISK CONSEQUENCES ILLNESS PREDISPOSITION INTERVENTION COGNITIONS BIOMARKERS
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:08
Last Modified : 17 May 2017 09:08
URI: http://epubs.surrey.ac.uk/id/eprint/822441

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800