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Preliminary development of the new individualized HDQoL questionnaire measuring quality of life in adult hypopituitarism.

McMillan, CV, Bradley, C, Gibney, J, Russell-Jones, DL and Sönksen, PH (2006) Preliminary development of the new individualized HDQoL questionnaire measuring quality of life in adult hypopituitarism. J Eval Clin Pract, 12 (5). pp. 501-514.

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Abstract

OBJECTIVES: The objectives were (1) to report the preliminary development of the Hormone Deficiency-dependent Quality of Life (HDQoL) questionnaire, a new individualized questionnaire in which respondents rate personally applicable domains for importance and impact of hormonal deficiency and its treatment; (2) to evaluate the HDQoL's psychometric properties for adults with hypopituitarism including growth hormone deficiency (GHD). METHODS: Internal consistency reliability, aspects of validity, and sensitivity to change of the HDQoL were investigated in: (1) a cross-sectional survey of 157 adults with treated or untreated GHD; (2) a randomized, placebo-controlled study of 3 months' growth hormone (GH) withdrawal from 12 of 21 GH-treated adults. RESULTS: Thirteen of the original 18 HDQoL domains were relevant and important for GH-deficient adults. The shorter 13-item HDQoL had excellent internal reliability (Cronbach's alpha coefficient = 0.914, n = 109), and was sensitive to sex differences (cross-sectional study): women perceived worse present QoL than men [t(149.8) = 2.33, P = 0.021]. The HDQoL was sensitive to change (GH-withdrawal study) with a significant between-group difference in change in domain scores for things I can do physically[t(16) = 2.47, P = 0.025, 2-tailed], patients withdrawn from GH reporting greater negative impact of hormone deficiency on this domain at end-point. Qualitative work resulted in the addition of seven new HDQoL domains, including energy and bodily pain. CONCLUSION: The HDQoL, although at an early stage of development, proved useful in identifying expected changes following GH withdrawal. The extended 20-item version is recommended for further evaluation in assessing the impact of hypopituitarism on QoL.

Item Type: Article
Authors :
NameEmailORCID
McMillan, CVUNSPECIFIEDUNSPECIFIED
Bradley, CUNSPECIFIEDUNSPECIFIED
Gibney, JUNSPECIFIEDUNSPECIFIED
Russell-Jones, DLdavidrussell-jones@nhs.netUNSPECIFIED
Sönksen, PHUNSPECIFIEDUNSPECIFIED
Date : October 2006
Identification Number : https://doi.org/10.1111/j.1365-2753.2006.00659.x
Uncontrolled Keywords : Adult, Cross-Sectional Studies, Female, Great Britain, Humans, Hypopituitarism, Laron Syndrome, Male, Middle Aged, Psychometrics, Quality of Life, State Medicine, Surveys and Questionnaires
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:05
Last Modified : 17 May 2017 09:05
URI: http://epubs.surrey.ac.uk/id/eprint/822228

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