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Assessment of the dielectric properties of drug sensitive and resistant leukaemic cells before and after ion channel blockers using dielectroplioresis

Duncan, L, Shelmerdine, H, Coley, HM and Labeed, FH (2006) Assessment of the dielectric properties of drug sensitive and resistant leukaemic cells before and after ion channel blockers using dielectroplioresis 2006 NSTI Nanotechnology Conference and Trade Show - NSTI Nanotech 2006 Technical Proceedings, 2. pp. 45-48.

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Abstract

Dielectrophoresis (DEP) is a phenomenon of induced particle motion in non-uniform electric fields. The effect is frequency dependent; by monitoring the motion of particles in AC fields and analysing the change in motion with frequency, it is possible to determine the electrical properties of single cells in lab-on-a-chip systems. In this paper we use DEP to study the electrical properties of drug-sensitive and drug-resistant cancer cells before and after treatment with ion channel blocking agents, which give insight into the origin of cytoplasmic differences shown to have a significant bearing on the origin of drug resistance in cancer.

Item Type: Article
Authors :
NameEmailORCID
Duncan, LUNSPECIFIEDUNSPECIFIED
Shelmerdine, HUNSPECIFIEDUNSPECIFIED
Coley, HMh.coley@surrey.ac.ukUNSPECIFIED
Labeed, FHf.labeed@surrey.ac.ukUNSPECIFIED
Date : 8 December 2006
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 09:02
Last Modified : 17 May 2017 14:39
URI: http://epubs.surrey.ac.uk/id/eprint/821956

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