The corticotropin-releasing factor-hypocretin connection: Implications in stress response and addiction

Paneda, C, Winsky-Sommerer, R, Boutrel, B and de Lecea, L (2005) The corticotropin-releasing factor-hypocretin connection: Implications in stress response and addiction DRUG NEWS PERSPECT, 18 (4). pp. 250-255.

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Abstract

The hypothalamic neuropeptides hypocretins (orexins) play a crucial role in the stability of arousal and alertness. Recent data have raised the hypothesis that hypocretin neurons are also part of the circuitries that mediate the hypothalamic stress response. In particular, we have recently demonstrated that corticotrophin-releasing factor (CRF)immunoreactive terminals make direct synaptic contacts with hypocretin-expressing neurons and that numerous hypocretinergic neurons express the CRF-R1/2 receptors. Furthermore, CRF excites hypocretinergic cells ex vivo through CRF-R1 receptors. Activation of hypocretinergic neurons in response to acute stress is severely impaired in CRF-R1 knockout mice. Moreover, the stress response is impaired in hypocretin-deficient mice. We propose that upon stressor stimuli, CRF stimulates the release of hypocretins, and this circuit contributes to activation and maintenance of arousal associated with the stress response and addiction. (c) 2005 Prous Science. All rights reserved.

Item Type:	Article
Divisions :	Surrey research (other units)
Authors :	Name Email ORCID Paneda, C Winsky-Sommerer, R r.winsky-sommerer@surrey.ac.uk Boutrel, B de Lecea, L
Date :	May 2005
DOI :	10.1358/dnp.2005.18.4.908659
Uncontrolled Keywords :	BRAIN-STIMULATION REWARD, HYPOTHALAMIC PARAVENTRICULAR NUCLEUS, RECEPTOR MESSENGER-RNA, INDUCED REINSTATEMENT, OREXIN RECEPTORS, RAT-BRAIN, STRIA TERMINALIS, SATIETY SEQUENCE, COCAINE-SEEKING, BED NUCLEUS
Depositing User :	Symplectic Elements
Date Deposited :	17 May 2017 08:55
Last Modified :	24 Jan 2020 15:23
URI:	http://epubs.surrey.ac.uk/id/eprint/821479

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