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Ceftriaxone-Resistant Salmonella enterica Serotype Typhimurium Sequence Type 313 from Kenyan Patients Is Associated with the blaCTX-M-15 Gene on a Novel IncHI2 Plasmid

Kariuki, S, Okoro, C, Kiiru, J, Njoroge, S, Omuse, G, Langridge, G, Kingsley, RA, Dougan, G and Revathi, R (2015) Ceftriaxone-Resistant Salmonella enterica Serotype Typhimurium Sequence Type 313 from Kenyan Patients Is Associated with the blaCTX-M-15 Gene on a Novel IncHI2 Plasmid Antimicrobial Agents and Chemotherapy, 59 (6). pp. 3133-3139.

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Abstract

Multidrug-resistant bacteria pose a major challenge to the clinical management of infections in resource-poor settings. Although nontyphoidal Salmonella (NTS) bacteria cause predominantly enteric self-limiting illness in developed countries, NTS is responsible for a huge burden of life-threatening bloodstream infections in sub-Saharan Africa. Here, we characterized nine S. Typhimurium isolates from an outbreak involving patients who initially failed to respond to ceftriaxone treatment at a referral hospital in Kenya. These Salmonella enterica serotype Typhimurium isolates were resistant to ampicillin, chloramphenicol, cefuroxime, ceftriaxone, aztreonam, cefepime, sulfamethoxazole-trimethoprim, and cefpodoxime. Resistance to β-lactams, including to ceftriaxone, was associated with carriage of a combination of blaCTX-M-15, blaOXA-1, and blaTEM-1 genes. The genes encoding resistance to heavy-metal ions were borne on the novel IncHI2 plasmid pKST313, which also carried a pair of class 1 integrons. All nine isolates formed a single clade within S. Typhimurium ST313, the major clone of an ongoing invasive NTS epidemic in the region. This emerging ceftriaxone-resistant clone may pose a major challenge in the management of invasive NTS in sub-Saharan Africa.

Item Type: Article
Subjects : Biosciences
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
AuthorsEmailORCID
Kariuki, SUNSPECIFIEDUNSPECIFIED
Okoro, CUNSPECIFIEDUNSPECIFIED
Kiiru, JUNSPECIFIEDUNSPECIFIED
Njoroge, SUNSPECIFIEDUNSPECIFIED
Omuse, GUNSPECIFIEDUNSPECIFIED
Langridge, GUNSPECIFIEDUNSPECIFIED
Kingsley, RAUNSPECIFIEDUNSPECIFIED
Dougan, GUNSPECIFIEDUNSPECIFIED
Revathi, RUNSPECIFIEDUNSPECIFIED
Date : June 2015
Identification Number : https://doi.org/10.1128/AAC.00078-15
Copyright Disclaimer : Copyright © 2015, Kariuki et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license.
Depositing User : Symplectic Elements
Date Deposited : 08 May 2017 09:28
Last Modified : 08 May 2017 09:28
URI: http://epubs.surrey.ac.uk/id/eprint/814122

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