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Role of the enterocyte in fructose-induced hypertriglyceridaemia

Steenson, Simon, Umpleby, Margot, Lovegrove, JA, Jackson, KG and Fielding, Barbara (2017) Role of the enterocyte in fructose-induced hypertriglyceridaemia Nutrients, 9 (4), 349.

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Abstract: Dietary fructose has been linked to an increased post-prandial triglyceride (TG) level, which is an established independent risk factor for cardiovascular disease. Although much research has focused on the effects of fructose consumption on liver-derived very-low density lipoprotein (VLDL), emerging evidence also suggests that fructose may raise post-prandial TG levels by affecting the metabolism of enterocytes of the small intestine. Enterocytes have become well recognised for their ability to transiently store lipids following a meal and to thus control post-prandial TG levels according to the rate of chylomicron (CM) lipoprotein synthesis and secretion. The influence of fructose consumption on several aspects of enterocyte lipid metabolism are discussed, including de novo lipogenesis, apolipoprotein B48 and CM-TG production, based on the findings of animal and human isotopic tracer studies. Methodological issues affecting the interpretation of fructose studies conducted to date are highlighted, including the accurate separation of CM and VLDL. Although the available evidence to date is limited, disruption of enterocyte lipid metabolism may make a meaningful contribution to the hypertriglyceridaemia often associated with fructose consumption.

Item Type: Article
Subjects : Biosciences and Medicine
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Lovegrove, JA
Jackson, KG
Date : 1 April 2017
DOI : 10.3390/nu9040349
Copyright Disclaimer : © 2017 by the authors. Submitted for possible open access publication under the terms and conditions of the Creative Commons Attribution (CC-BY) license (
Uncontrolled Keywords : fructose; chylomicron; very low-density lipoprotein; triglyceride-rich lipoproteins; cardiovascular disease; de novo lipogenesis; post-prandial; apoB48; gluconeogenesis; glucagon-like peptide;
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 02 May 2017 17:26
Last Modified : 16 Jan 2019 17:14

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