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Clinical Features, Imaging Characteristics, and Long-term Outcome of Dogs with Cranial Meningocele or Meningoencephalocele.

Lazzerini, K, Gutierrez-Quintana, R, Jose-Lopez, R, McConnell, F, Goncalves, R, McMurrough, J, De Decker, S, Muir, C, Priestnall, SL, Mari, L , Stabile, F, De Risio, L, Loeffler, C, Tauro, A, Rusbridge, Clare, Rodenas, S, Anor, S, de la Fuente, C, Fischer, A, Bruehschwein, A, Penderis, J and Guevar, J (2017) Clinical Features, Imaging Characteristics, and Long-term Outcome of Dogs with Cranial Meningocele or Meningoencephalocele. Journal of Veterinary Internal Medicine, 31. pp. 505-512.

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Abstract

Background: The term meningoencephalocele (MEC) describes a herniation of cerebral tissue and meninges through a defect in the cranium, whereas a meningocele (MC) is a herniation of the meninges alone. Hypothesis/Objectives: To describe the clinical features, magnetic resonance imaging (MRI) characteristics, and outcomes of dogs with cranial MC and MEC. Animals: Twenty-two client-owned dogs diagnosed with cranial MC or MEC. Methods: Multicentric retrospective descriptive study. Clinical records of 13 institutions were reviewed. Signalment, clinical history, neurologic findings and MRI characteristics as well as treatment and outcome were recorded and evaluated. Results: Most affected dogs were presented at a young age (median, 6.5 months; range, 1 month – 8 years). The most common presenting complaints were seizures and behavioral abnormalities. Intranasal MEC was more common than parietal MC. Magnetic resonance imaging identified meningeal enhancement of the protruded tissue in 77% of the cases. Porencephaly was seen in all cases with parietal MC. Cerebrospinal fluid (CSF) analysis identified mild abnormalities in 4 of 11 cases. Surgery was not performed in any affected dog. Seventeen patients were treated medically, and seizures were adequately controlled with anti-epileptic drugs in 10 dogs. Dogs with intranasal MEC and mild neurologic signs had a fair prognosis with medical treatment. Conclusion and clinical importance: Although uncommon, MC and MEC should be considered as a differential diagnosis in young dogs presenting with seizures or alterations in behavior. Medical treatment is a valid option with a fair prognosis when the neurologic signs are mild.

Item Type: Article
Subjects : Veterinary Medicine
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
NameEmailORCID
Lazzerini, KUNSPECIFIEDUNSPECIFIED
Gutierrez-Quintana, RUNSPECIFIEDUNSPECIFIED
Jose-Lopez, RUNSPECIFIEDUNSPECIFIED
McConnell, FUNSPECIFIEDUNSPECIFIED
Goncalves, RUNSPECIFIEDUNSPECIFIED
McMurrough, JUNSPECIFIEDUNSPECIFIED
De Decker, SUNSPECIFIEDUNSPECIFIED
Muir, CUNSPECIFIEDUNSPECIFIED
Priestnall, SLUNSPECIFIEDUNSPECIFIED
Mari, LUNSPECIFIEDUNSPECIFIED
Stabile, FUNSPECIFIEDUNSPECIFIED
De Risio, LUNSPECIFIEDUNSPECIFIED
Loeffler, CUNSPECIFIEDUNSPECIFIED
Tauro, AUNSPECIFIEDUNSPECIFIED
Rusbridge, Clarec.rusbridge@surrey.ac.ukUNSPECIFIED
Rodenas, SUNSPECIFIEDUNSPECIFIED
Anor, SUNSPECIFIEDUNSPECIFIED
de la Fuente, CUNSPECIFIEDUNSPECIFIED
Fischer, AUNSPECIFIEDUNSPECIFIED
Bruehschwein, AUNSPECIFIEDUNSPECIFIED
Penderis, JUNSPECIFIEDUNSPECIFIED
Guevar, JUNSPECIFIEDUNSPECIFIED
Date : 2017
Identification Number : 10.1111/jvim.14638
Copyright Disclaimer : Copyright © 2017 The Authors. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Uncontrolled Keywords : Cerebral malformation; Cranioschisis; Porencephaly; Seizures
Depositing User : Symplectic Elements
Date Deposited : 02 May 2017 15:22
Last Modified : 25 Jul 2017 09:43
URI: http://epubs.surrey.ac.uk/id/eprint/814084

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