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Novel decay dynamics revealed for virus-mediated drug activation in cytomegalovirus infection

Rose, J, Emery, Vincent, Kumar, D, Asberg, A, Hartmann, A, Jardine, AG, Bignamini, AA, Humar, A and Neumann, AU (2017) Novel decay dynamics revealed for virus-mediated drug activation in cytomegalovirus infection PLoS Pathogens, 13 (4), e1006299.

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Abstract

Cytomegalovirus (CMV) remains a cause of disease in individuals with weakened immune systems such as patients undergoing organ transplantation. The mainstay of treatment for CMV is ganciclovir: a CMV-specific drug that looks like a building block of the viral DNA and which requires activation by a protein contained within CMV. Understanding how patients respond to treatment can lead to a better understanding of the basic biology of CMV in the human and also help to optimize treatment regimens. In this study we observed that following treatment of CMV disease in organ transplant patients, CMV viral loads decay according to four distinct patterns. We have developed a novel mathematical model that is able to describe each of these decay patterns. The model could potentially be used to assess how different patients respond to treatment in clinical settings and also to design better drug regimens as per patient. These results have striking implications in terms of how long patients should remain on treatment and provide new insight into CMV infection in the human host.

Item Type: Article
Subjects : Microbial and Cellular Sciences
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Microbial and Cellular Sciences
Authors :
NameEmailORCID
Rose, JUNSPECIFIEDUNSPECIFIED
Emery, Vincentv.emery@surrey.ac.ukUNSPECIFIED
Kumar, DUNSPECIFIEDUNSPECIFIED
Asberg, AUNSPECIFIEDUNSPECIFIED
Hartmann, AUNSPECIFIEDUNSPECIFIED
Jardine, AGUNSPECIFIEDUNSPECIFIED
Bignamini, AAUNSPECIFIEDUNSPECIFIED
Humar, AUNSPECIFIEDUNSPECIFIED
Neumann, AUUNSPECIFIEDUNSPECIFIED
Date : 13 April 2017
Identification Number : 10.1371/journal.ppat.1006299
Copyright Disclaimer : Copyright: © 2017 Rose et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Depositing User : Symplectic Elements
Date Deposited : 02 May 2017 14:34
Last Modified : 20 Jul 2017 13:57
URI: http://epubs.surrey.ac.uk/id/eprint/814082

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