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Commitment of Scaffold Proteins in the Onco-Biology of Human Colorectal Cancer and Liver Metastases after Oxaliplatin-based Chemotherapy

Rotoli, D, Morales, M, Ávila, J, Maeso, M, García, M, Mobasheri, Ali and Martín-Vasallo, P (2017) Commitment of Scaffold Proteins in the Onco-Biology of Human Colorectal Cancer and Liver Metastases after Oxaliplatin-based Chemotherapy International Journal of Molecular Sciences, 18 (4). p. 891.

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Abstract

Scaffold proteins play pivotal roles in the regulation of signaling pathways, integrating external and internal stimuli to various cellular outputs. We report the pattern of cellular and subcellular expression of scaffoldins angiomotin-like 2 (AmotL2), FK506 binding protein 5 (FKBP51) and IQ motif containing GTPase-activating protein 1 (IQGAP1) in colorectal cancer (CRC) and metastases in liver resected after oxaliplatin-based chemotherapy (CT). Positive immunostaining for the three scaffoldins was found in most cells in healthy colon, tumor, healthy liver and metastasized liver. The patterns of expression of AmotL2, FKBP51 and IQGAP1 show the greatest variability in immune system cells and neurons and glia cells and the least in blood vessel cells. The simultaneous subcellular localization in tumor cells and other cell types within the tumor suggest an involvement of these three scaffoldins in cancer biology, including a role in Epithelial Mesenchymal Transition. The display in differential localization and quantitative expression of AmotL2, FKBP51, and IQGAP1 could be used as biomarkers for more accurate tumor staging and as potential targets for anti-cancer therapeutics by blocking or slowing down their interconnecting functions. Tough further research needs to be done in order to improve these assessments.

Item Type: Article
Subjects : Veterinary Medicine
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
NameEmailORCID
Rotoli, DUNSPECIFIEDUNSPECIFIED
Morales, MUNSPECIFIEDUNSPECIFIED
Ávila, JUNSPECIFIEDUNSPECIFIED
Maeso, MUNSPECIFIEDUNSPECIFIED
García, MUNSPECIFIEDUNSPECIFIED
Mobasheri, Alia.mobasheri@surrey.ac.ukUNSPECIFIED
Martín-Vasallo, PUNSPECIFIEDUNSPECIFIED
Date : 22 April 2017
Identification Number : 10.3390/ijms18040891
Copyright Disclaimer : © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Uncontrolled Keywords : colorectal cancer; scaffold proteins; AmotL2; FKBP51; IQGAP1; metastasized liver; FOLFOX; oxaliplatin; pericytes; telocytes
Depositing User : Symplectic Elements
Date Deposited : 02 May 2017 14:13
Last Modified : 20 Jul 2017 13:53
URI: http://epubs.surrey.ac.uk/id/eprint/814080

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