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The effect of sodium-glucose co-transporter 2 (SGLT2) inhibitors on cardiometabolic profile; beyond the hypoglycaemic action

Lioudaki, E, Whyte, Martin, Stylianou, KG, Daphnis, EK and Ganotakis, ES (2017) The effect of sodium-glucose co-transporter 2 (SGLT2) inhibitors on cardiometabolic profile; beyond the hypoglycaemic action Cardiovascular Drugs and Therapy, 31 (2). pp. 215-225.

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Abstract

Type 2 diabetes mellitus (T2DM) has growing prevalence worldwide and major clinical implications, chiefly cardiovascular (CV) and renal disease burden. Sodium-glucose co-transporter (SGLT)2 inhibitors are a new drug class in the management of T2DM with a mechanism of action independent of insulin. In addition to their hypoglycaemic effect, SGLT2 inhibitors appear to have haemodynamic and nephroprotective effects. Studies have consistently showed a modest but significant blood pressure (BP) reduction. Metabolic benefits are also attributed to SGLT2 inhibitors with a modest but consistent body weight decrease recorded along with improvements in lipid profile and uric acid levels. Remarkable findings of significant cardioprotective effects came from the recent EMPA-REG study with a particular focus on heart failure. In the kidney, SGLT2 inhibitors reduce hyperfiltration, a precipitant of diabetic nephropathy.

Item Type: Article
Subjects : Nutrition
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Lioudaki, EUNSPECIFIEDUNSPECIFIED
Whyte, Martinm.b.whyte@surrey.ac.ukUNSPECIFIED
Stylianou, KGUNSPECIFIEDUNSPECIFIED
Daphnis, EKUNSPECIFIEDUNSPECIFIED
Ganotakis, ESUNSPECIFIEDUNSPECIFIED
Date : 25 April 2017
Identification Number : 10.1007/s10557-017-6724-3
Copyright Disclaimer : The final publication is available at Springer via http://dx.doi.org/10.1007/s10557-017-6724-3
Uncontrolled Keywords : Sodium-glucose co-transporter-2 Inhibitor Diabetes Kidney Cardiovascular Heart
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 26 Apr 2017 08:10
Last Modified : 13 Sep 2017 15:59
URI: http://epubs.surrey.ac.uk/id/eprint/814025

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