University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Supercritical fluid coating of API on excipient enhances drug release

Liu, Q, Huang, D, Lu, T, Seville, Jonathan, Xing, L and Leeke, GA (2016) Supercritical fluid coating of API on excipient enhances drug release Chemical Engineering Journal, 313. pp. 317-327.

[img]
Preview
Text
1-s2.0-S1385894716318125-main.pdf - Version of Record
Available under License : See the attached licence file.

Download (4MB) | Preview
[img]
Preview
Text (licence)
SRI_deposit_agreement.pdf
Available under License : See the attached licence file.

Download (33kB) | Preview

Abstract

A process to coat particles of active pharmaceutical ingredient (API) onto microcrystalline cellulose (MCC) excipient shows promise as a new way to dosage forms showing enhanced drug release. The process consists of a fluidized bed operated at elevated pressure in which API particles are precipitated from a Supercritical Anti-Solvent process (SAS). MCC particles were used as an excipient in the fluidized bed and collect the SAS-generated API particles. Naringin was selected as the model API to coat onto MCC. A number of operational parameters of the process were investigated: fluidization velocity, coating pressure, temperature, concentration of drug solution, drug solution flow rate, drug mass, organic solvent, MCC mass and size and CO2-to-organic solution ratio. SEM and SPM analyses showed that the MCC particle surfaces were covered with near-spherical nanoparticles with a diameter of approximately 100– 200 nm, substantially smaller than the as-received API material. XRD showed that naringin changed from crystalline to amorphous during processing. The coated particles resulting from the SAS fluidized bed process have a higher loading of API, gave faster release rates and higher release ratios in comparison with those produced using a conventional fluidized bed coating process. The approach could be transferred to other industries where release is important such as agrochemical, cosmetic and food.

Item Type: Article
Subjects : Chemical & Process Engineering
Divisions : Faculty of Engineering and Physical Sciences > Chemical and Process Engineering
Authors :
NameEmailORCID
Liu, QUNSPECIFIEDUNSPECIFIED
Huang, DUNSPECIFIEDUNSPECIFIED
Lu, TUNSPECIFIEDUNSPECIFIED
Seville, JonathanJ.P.K.Seville@surrey.ac.ukUNSPECIFIED
Xing, LUNSPECIFIEDUNSPECIFIED
Leeke, GAUNSPECIFIEDUNSPECIFIED
Date : 18 December 2016
Identification Number : 10.1016/j.cej.2016.12.066
Copyright Disclaimer : Copyright 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Uncontrolled Keywords : Supercritical Anti-Solvent Fluidized bed coating Naringin Release profile Nanoparticles
Depositing User : Symplectic Elements
Date Deposited : 25 Apr 2017 14:24
Last Modified : 25 Jul 2017 09:49
URI: http://epubs.surrey.ac.uk/id/eprint/814017

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800