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Adverse Effects of Plant Food Supplements Self-Reported by Consumers in the PlantLIBRA Survey Involving Six European Countries

Restani, P, Di Lorenzo, C, Garcia-Alvarez, A, Badea, M, Ceschi, A, Egan, B, Dima, L, Luede, S, Maggi, FM, Marculescu, A, Mila-Villarroel, R, Raats, MM, Ribas-Barba, L, Uusitalo, L and Serra-Majem, L (2016) Adverse Effects of Plant Food Supplements Self-Reported by Consumers in the PlantLIBRA Survey Involving Six European Countries PLOS ONE, 11 (2), ARTN e0150.

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Abstract

Background The use of food supplements containing botanicals is increasing in European markets. Although intended to maintain the health status, several cases of adverse effects to Plant Food Supplements (PFS) have been described. Objectives To describe the self-reported adverse effects collected during the European PlantLIBRA PFS Consumer Survey 2011–2012, with a critical evaluation of the plausibility of the symptomatology reported using data from the literature and from the PlantLIBRA Poisons Centers' survey. Subjects/Setting From the total sample of 2359 consumers involved in the consumers' survey, 82 subjects reported adverse effects due to a total of 87 PFS. Results Cases were self-reported, therefore causality was not classified on the basis of clinical evidence, but by using the frequency/strength of adverse effects described in scientific papers: 52 out of 87 cases were defined as possible (59.8%) and 4 as probable (4.6%). Considering the most frequently cited botanicals, eight cases were due to Valeriana officinalis (garden valerian); seven to Camellia sinensis (tea); six to Ginkgo biloba (Maidenhair tree) and Paullinia cupana (guarana). Most adverse events related to the gastrointestinal tract, nervous and cardiovascular systems. Conclusions Comparing the data from this study with those published in scientific papers and obtained by the PlantLIBRA Poisons Centers' survey, some important conclusions can be drawn: severe adverse effects to PFS are quite rare, although mild or moderate adverse symptoms can be present. Data reported in this paper can help health professionals (and in particular family doctors) to become aware of possible new problems associated with the increasing use of food supplements containing botanicals.

Item Type: Article
Authors :
NameEmailORCID
Restani, PUNSPECIFIEDUNSPECIFIED
Di Lorenzo, CUNSPECIFIEDUNSPECIFIED
Garcia-Alvarez, AUNSPECIFIEDUNSPECIFIED
Badea, MUNSPECIFIEDUNSPECIFIED
Ceschi, AUNSPECIFIEDUNSPECIFIED
Egan, BUNSPECIFIEDUNSPECIFIED
Dima, LUNSPECIFIEDUNSPECIFIED
Luede, SUNSPECIFIEDUNSPECIFIED
Maggi, FMUNSPECIFIEDUNSPECIFIED
Marculescu, AUNSPECIFIEDUNSPECIFIED
Mila-Villarroel, RUNSPECIFIEDUNSPECIFIED
Raats, MMUNSPECIFIEDUNSPECIFIED
Ribas-Barba, LUNSPECIFIEDUNSPECIFIED
Uusitalo, LUNSPECIFIEDUNSPECIFIED
Serra-Majem, LUNSPECIFIEDUNSPECIFIED
Date : 29 February 2016
Identification Number : https://doi.org/10.1371/journal.pone.0150089
Copyright Disclaimer : © 2016 Restani et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Uncontrolled Keywords : Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, BODY-WEIGHT REDUCTION, DIETARY-SUPPLEMENTS, MONASCUS-PURPUREUS, CONTROLLED-TRIAL, DOUBLE-BLIND, EFFICACY, GINSENG, HYPERLIPIDEMIA, ALOPECIA, THERAPY
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 27 Jun 2017 16:07
Last Modified : 27 Jun 2017 16:08
URI: http://epubs.surrey.ac.uk/id/eprint/813896

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