University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Potential for use of creatine supplementation following mild traumatic brain injury

Dean, Philip, Arikan, G, Opitz, Bertram and Sterr, Annette (2017) Potential for use of creatine supplementation following mild traumatic brain injury Concussion.

[img]
Preview
Text
Dean_2017_REVIEW_Creatine_mTBI.pdf - Accepted version Manuscript
Available under License : See the attached licence file.

Download (926kB) | Preview
[img]
Preview
PDF (licence)
SRI_deposit_agreement.pdf
Available under License : See the attached licence file.

Download (33kB) | Preview

Abstract

There is significant overlap between the neuropathology of mild traumatic brain injury (mTBI) and the cellular role of creatine, as well as evidence of neural creatine alterations after mTBI. Creatine supplementation has not been researched in mTBI, but shows some potential as a neuroprotective when administered prior to or after TBI. Consistent with creatine’s cellular role, supplementation reduced neuronal damage, protected against the effects of cellular energy crisis and improved cognitive and somatic symptoms. A variety of factors influencing the efficacy of creatine supplementation are highlighted, as well as avenues for future research into the potential of supplementation as an intervention for mTBI. In particular, the slow neural uptake of creatine may mean that greater effects are achieved by pre-emptive supplementation in at-risk groups.

Item Type: Article
Subjects : Psychology
Divisions : Faculty of Health and Medical Sciences > School of Psychology
Authors :
NameEmailORCID
Dean, PhilipP.Dean@surrey.ac.ukUNSPECIFIED
Arikan, GUNSPECIFIEDUNSPECIFIED
Opitz, Bertramb.opitz@surrey.ac.ukUNSPECIFIED
Sterr, AnnetteA.Sterr@surrey.ac.ukUNSPECIFIED
Date : 21 March 2017
Identification Number : 10.2217/cnc-2016-0016
Copyright Disclaimer : © The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 License.
Uncontrolled Keywords : behavioral symptoms • brain injury • clinical outcome • concussion • creatine • magnetic resonance spectroscopy • mild TBI • neurobiology • neuroprotection • postconcussion syndrome • treatment
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 28 Mar 2017 09:10
Last Modified : 19 Jul 2017 13:50
URI: http://epubs.surrey.ac.uk/id/eprint/813859

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800