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Intratumoral and peritumoral expressions of CD68 and CD206 in hepatocellular carcinoma and their prognostic value

Ren, C-X, Leng, R-X, Fan, Y-G, Pan, H-F, Li, B-Z, Wu, Changhao, Wu, Q, Wang, N-N, Xiong, Q-R, Geng, X-P and Ye, D-Q (2017) Intratumoral and peritumoral expressions of CD68 and CD206 in hepatocellular carcinoma and their prognostic value Oncology Reports: an international journal devoted to fundamental and applied research in oncology, 38 (2). pp. 886-898.

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Abstract

Purpose The aims of this study were to determine whether the changes in density and location of CD68-positive and CD206-positive macrophages contribute to progression of hepatocellular carcinoma (HCC) and to evaluate prognostic values of these cells in post-surgical patients. Methods A retrospective study involving 268 HCC patients was conducted. CD68-positive and CD206-positive macrophage infiltration in HCC tissues and adjacent tissues was examined by immunohistochemistry (IHC) and the relationship between clinicopathologic features and prognosis was analyzed. Receiver operating characteristics (ROC) curve was used to calculate diagnostic accuracy. Results There was an increase in CD68-positive and CD206-positive macrophage infiltrations in adjacent tumor tissues compared with tumor tissues. ROC curve identified their optimal diagnostic cutoff values. The survival analysis showed that increased CD68 expression in adjacent tissues conferred superior overall survival (OS) and disease-free survival (DFS), while increase of CD206 in tumor yielded inferior OS and DFS. Cox regression analysis suggested both CD68-positive macrophages in adjacent area and intratumor CD206-positive macrophages as independent prognostic biomarkers for post-surgical HCC patients. Finally, a combination of CD68/CD206 and HBV-positive further improved prognostic stratification, especially in DFS. These results provide the first evidence for region- and subset-dependent involvement of CD68 and CD206 cells in HCC progression. A combination of CD68/CD206 density and HBV-positivity improves further predictive value for post-operative recurrence of HCC. Conclusion Quantification of CD68/CD206 macrophages and their distribution can be exploited for better postsurgical management of HCC patients. These findings provide a basis for developing novel treatment strategies aimed at re-educating macrophages in tumor microenvironment.

Item Type: Article
Subjects : Biosciences and Medicine
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Ren, C-XUNSPECIFIEDUNSPECIFIED
Leng, R-XUNSPECIFIEDUNSPECIFIED
Fan, Y-GUNSPECIFIEDUNSPECIFIED
Pan, H-FUNSPECIFIEDUNSPECIFIED
Li, B-ZUNSPECIFIEDUNSPECIFIED
Wu, ChanghaoC.Wu@surrey.ac.ukUNSPECIFIED
Wu, QUNSPECIFIEDUNSPECIFIED
Wang, N-NUNSPECIFIEDUNSPECIFIED
Xiong, Q-RUNSPECIFIEDUNSPECIFIED
Geng, X-PUNSPECIFIEDUNSPECIFIED
Ye, D-QUNSPECIFIEDUNSPECIFIED
Date : 21 June 2017
Identification Number : 10.3892/or.2017.5738
Copyright Disclaimer : Copyright 2017 Spandidos Publications
Uncontrolled Keywords : Hepatocellular carcinoma, Tumor-associated macrophages, CD68, CD206, Prognosis
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 24 Mar 2017 08:36
Last Modified : 07 Sep 2017 13:19
URI: http://epubs.surrey.ac.uk/id/eprint/813845

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