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Rift Valley fever virus: Strategies for maintenance, survival and vertical transmission in mosquitoes

Lumley, Sarah, Horton, Daniel, Hernandez-Triana, LLM, Johnson, N, Fooks, AR and Hewson, R (2017) Rift Valley fever virus: Strategies for maintenance, survival and vertical transmission in mosquitoes Journal of General Virology, 98 (5). pp. 875-887.

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Abstract

Rift Valley fever virus (RVFV) is a mosquito-borne arbovirus causing severe disease in humans and ruminants. Spread of RVFV out of Africa has raised concerns that it could emerge in Europe or the USA. Virus persistence is dependent on successful infection of, replication in, and transmission to susceptible vertebrate and invertebrate hosts, modulated by virus-host and vector-virus interactions. The principal accepted theory for the long term maintenance of RVFV involves vertical transmission (VT) of virus to mosquito progeny, with the virus surviving long inter-epizootic periods within the egg. This VT hypothesis however, is yet to be comprehensively proven. Here, evidence for and against the VT of RVFV is reviewed along with the identification of factors limiting its detection in natural and experimental data. The observation of VT for other arboviruses in the genera alphavirus, flavivirus and orthobunyavirus are discussed within the context of RVFV. The review concludes that VT of RVFV is likely but that current data are insufficient to irrefutably prove this hypothesis.

Item Type: Article
Subjects : Veterinary Medicine
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
NameEmailORCID
Lumley, Sarahs.lumley@surrey.ac.ukUNSPECIFIED
Horton, Danield.horton@surrey.ac.ukUNSPECIFIED
Hernandez-Triana, LLMUNSPECIFIEDUNSPECIFIED
Johnson, NUNSPECIFIEDUNSPECIFIED
Fooks, ARUNSPECIFIEDUNSPECIFIED
Hewson, RUNSPECIFIEDUNSPECIFIED
Date : 30 May 2017
Identification Number : https://doi.org/10.1099/jgv.0.000765
Copyright Disclaimer : Copyright 2017 Microbiology Society. This is the author's accepted version.
Uncontrolled Keywords : Rift Valley fever virus, arbovirus, mosquito, vector, vertical transmission, transovarian transmission
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 23 Mar 2017 13:58
Last Modified : 04 Jul 2017 17:19
URI: http://epubs.surrey.ac.uk/id/eprint/813844

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