University of Surrey

Test tubes in the lab Research in the ATI Dance Research

New advances in CMV and immunosenescence

Sansoni, P, Vescovini, R, Fagnoni, FF, Akbar, A, Arens, R, Chiu, Y-L, Čičin-Šain, L, Dechanet-Merville, J, Derhovanessian, E, Ferrando-Martinez, S , Franceschi, C, Frasca, D, Fulöp, T, Furman, D, Gkrania-Klotsas, E, Goodrum, F, Grubeck-Loebenstein, B, Hurme, M, Kern, F, Lilleri, D, López-Botet, M, Maier, AB, Marandu, T, Marchant, A, Matheï, C, Moss, P, Muntasell, A, Remmerswaal, EBM, Riddell, N, Rothe, K, Sauce, D, Shin, E-C, Simanek, AM, Smithey, MJ, Söderberg-Nauclér, C, Solana, R, Thomas, PG, van Lier, R, Pawelec, G and Nikolich-Zugich, J (2014) New advances in CMV and immunosenescence Experimental Gerontology, 55. pp. 54-62.

[img]
Preview
Text
New advances in CMV and immunosenescence.pdf - Version of Record
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (481kB) | Preview
[img]
Preview
Text (licence)
SRI_deposit_agreement.pdf
Available under License : See the attached licence file.

Download (33kB) | Preview

Abstract

Immunosenescence, defined as the age-associated dysregulation and dysfunction of the immune system, is characterized by impaired protective immunity and decreased efficacy of vaccines. An increasing number of immunological, clinical and epidemiological studies suggest that persistent Cytomegalovirus (CMV) infection is associated with accelerated aging of the immune system and with several age-related diseases. However, current evidence on whether and how human CMV (HCMV) infection is implicated in immunosenescence and in age-related diseases remains incomplete and many aspects of CMV involvement in immune aging remain controversial. The attendees of the 4th International Workshop on “CMV & Immunosenescence”, held in Parma, Italy, 25–27th March, 2013, presented and discussed data related to these open questions, which are reported in this commentary.

Item Type: Article
Subjects : Biosciences
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Sansoni, PUNSPECIFIEDUNSPECIFIED
Vescovini, RUNSPECIFIEDUNSPECIFIED
Fagnoni, FFUNSPECIFIEDUNSPECIFIED
Akbar, AUNSPECIFIEDUNSPECIFIED
Arens, RUNSPECIFIEDUNSPECIFIED
Chiu, Y-LUNSPECIFIEDUNSPECIFIED
Čičin-Šain, LUNSPECIFIEDUNSPECIFIED
Dechanet-Merville, JUNSPECIFIEDUNSPECIFIED
Derhovanessian, EUNSPECIFIEDUNSPECIFIED
Ferrando-Martinez, SUNSPECIFIEDUNSPECIFIED
Franceschi, CUNSPECIFIEDUNSPECIFIED
Frasca, DUNSPECIFIEDUNSPECIFIED
Fulöp, TUNSPECIFIEDUNSPECIFIED
Furman, DUNSPECIFIEDUNSPECIFIED
Gkrania-Klotsas, EUNSPECIFIEDUNSPECIFIED
Goodrum, FUNSPECIFIEDUNSPECIFIED
Grubeck-Loebenstein, BUNSPECIFIEDUNSPECIFIED
Hurme, MUNSPECIFIEDUNSPECIFIED
Kern, FUNSPECIFIEDUNSPECIFIED
Lilleri, DUNSPECIFIEDUNSPECIFIED
López-Botet, MUNSPECIFIEDUNSPECIFIED
Maier, ABUNSPECIFIEDUNSPECIFIED
Marandu, TUNSPECIFIEDUNSPECIFIED
Marchant, AUNSPECIFIEDUNSPECIFIED
Matheï, CUNSPECIFIEDUNSPECIFIED
Moss, PUNSPECIFIEDUNSPECIFIED
Muntasell, AUNSPECIFIEDUNSPECIFIED
Remmerswaal, EBMUNSPECIFIEDUNSPECIFIED
Riddell, NUNSPECIFIEDUNSPECIFIED
Rothe, KUNSPECIFIEDUNSPECIFIED
Sauce, DUNSPECIFIEDUNSPECIFIED
Shin, E-CUNSPECIFIEDUNSPECIFIED
Simanek, AMUNSPECIFIEDUNSPECIFIED
Smithey, MJUNSPECIFIEDUNSPECIFIED
Söderberg-Nauclér, CUNSPECIFIEDUNSPECIFIED
Solana, RUNSPECIFIEDUNSPECIFIED
Thomas, PGUNSPECIFIEDUNSPECIFIED
van Lier, RUNSPECIFIEDUNSPECIFIED
Pawelec, GUNSPECIFIEDUNSPECIFIED
Nikolich-Zugich, JUNSPECIFIEDUNSPECIFIED
Date : July 2014
Identification Number : 10.1016/j.exger.2014.03.020
Copyright Disclaimer : © 2014 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
Uncontrolled Keywords : Immunosenescence, Cytomegalovirus infection, Immune homeostasis, Pathologies of aging, Virus-host interaction
Depositing User : Symplectic Elements
Date Deposited : 13 Mar 2017 14:42
Last Modified : 31 Oct 2017 19:11
URI: http://epubs.surrey.ac.uk/id/eprint/813760

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800