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Cytomegalovirus in pregnancy and the neonate [version 1; referees: 2 approved]

Emery, Vincent and Lazzarotto, T (2017) Cytomegalovirus in pregnancy and the neonate [version 1; referees: 2 approved] F1000Research 2017, 6 (138).

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Abstract

Congenital cytomegalovirus (CMV) remains a leading cause of disability in children. Understanding the pathogenesis of infection from the mother via the placenta to the neonate is crucial if we are to produce new interventions and provide supportive mechanisms to improve the outcome of congenitally infected children. In recent years, some major goals have been achieved, including the diagnosis of primary maternal CMV infection in pregnant women by using the anti-CMV IgG avidity test and the diagnosis and prognosis of foetal CMV infection by using polymerase chain reaction real-time tests to detect and quantify the virus in amniotic fluid. This review summarises recent advances in our understanding and highlights where challenges remain, especially in vaccine development and anti-viral therapy of the pregnant woman and the neonate. Currently, no therapeutic options during pregnancy are available except those undergoing clinical trials, whereas valganciclovir treatment is recommended for congenitally infected neonates with moderately to severely symptomatic disease.

Item Type: Article
Subjects : Microbial and Cellular Sciences
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Emery, Vincentv.emery@surrey.ac.ukUNSPECIFIED
Lazzarotto, TUNSPECIFIEDUNSPECIFIED
Date : 14 February 2017
Identification Number : 10.12688/f1000research.10276.1
Copyright Disclaimer : Copyright: © 2017 Emery VC and Lazzarotto T. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Depositing User : Symplectic Elements
Date Deposited : 22 Feb 2017 18:43
Last Modified : 12 Sep 2017 17:55
URI: http://epubs.surrey.ac.uk/id/eprint/813612

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