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Compartmentalized dynamics of cytomegalovirus replication in treated congenital infection

Luck, SE, Emery, Vincent, Atkinson, C, Sharland, M and Griffiths, PD (2016) Compartmentalized dynamics of cytomegalovirus replication in treated congenital infection Journal of Clinical Virology, 82 (Sept 2). pp. 152-158.

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Background Cytomegalovirus (CMV) is the most prevalent congenital infection in developed countries. A significant number of infected infants develop long-term neurodevelopmental and hearing impairment irrespective of whether disease is detectable at birth. Studies of viral load and replication dynamics have informed the treatment of CMV in adult populations but no similar data exist in neonates. Objectives To study CMV virus kinetics in different body fluids of babies treated for congenital infection. Study design CMV virus load was sequentially analyzed in blood, urine and saliva in 17 babies treated for symptomatic congenital CMV infection. Results Virus was detectable in the urine and saliva of all babies at baseline but in only 15/17 in blood. At the end of 6 weeks of antiviral treatment CMV remained detectable in 9/14 blood samples, 9/12 urine samples and 4/7 salivary swabs. Median half-life (T1/2) of virus decline in blood was 2.4 days (IQR 1.9–3.3) and basic reproductive number (Ro) was 2.3. Although T1/2 values were similar in urine and saliva to those observed in blood, virus dynamics differed both during and after treatment. Conclusions T1/2 and Ro in blood in this group of neonates were similar to values derived from studies of immunocompromised adults. The persistent viremia observed in treated neonates cannot therefore be adequately explained by the virus dynamics early in treatment. The different dynamics exhibited in blood and urine suggests that studying changes in distinct body compartments may assist in further understanding long-term manifestations of disease.

Item Type: Article
Subjects : Microbial and Cellular Sciences
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
Date : 27 July 2016
Identification Number : 10.1016/j.jcv.2016.07.018
Copyright Disclaimer : © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license
Uncontrolled Keywords : Congenital cytomegalovirus; Virus half-life; Virus dynamics; Antiviral treatment
Depositing User : Symplectic Elements
Date Deposited : 22 Feb 2017 18:21
Last Modified : 12 Sep 2017 17:55

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