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Subchondral bone and ligament changes precede cartilage degradation in guinea pig osteoarthritis

Quasnichka, H (2006) Subchondral bone and ligament changes precede cartilage degradation in guinea pig osteoarthritis Biorheology, 43 (3-4). pp. 389-397.

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Abstract

There is increasing recognition that osteoarthritis (OA) is a complex disease involving the whole synovial joint, rather than the articular cartilage alone, however its aetiology and pathogenesis is not understood. Our initial studies revealed elevated turnover of bone and ligament collagen in human and mouse OA, respectively. To investigate the relative appearance of pathology in cartilage, bone and ligament, we studied the progression of spontaneous OA in the Dunkin–Hartley (DH) guinea pig knee, and compared with age-matched control Bristol Strain 2 (BS2) knees. The classical radiographic OA score of the DH knees compared to BS2 knees was 2-fold higher at 24 weeks of age. The patella perimeter and subchondral bone density was significantly greater in the DHs at 24 and 36 weeks compared to BS2. The femoral intercondylar notch width was found to be significantly lower in the DHs at 24 and 36 weeks, compared to BS2, indicating bone remodelling at the cruciate ligament (CL) insertion site. We found significantly greater laxity of the DH anterior CL at 12, 16 and 20 weeks compared to BS2. This elevated laxity was associated with increased remodelling of the CLs, based on markers of collagen turnover, and occurred prior to bone and cartilage pathology. We propose that the laxity of the CL leads to remodelling of the subchondral bone, and intercondylar notch, due to a change in load through the joint. Remodelling of the CLs and bone occurs prior to and concomitant with histopathological changes in the articular cartilage respectively, demonstrating the fundamental role of the ligament and subchondral bone in the aetiology of knee OA.

Item Type: Article
Subjects : Veterinary Medicine
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
NameEmailORCID
Quasnichka, HUNSPECIFIEDUNSPECIFIED
Date : 2006
Copyright Disclaimer : © 2005 IOS Press
Uncontrolled Keywords : Osteoarthritis, Subchondral bone, Ligaments, Collagen, Metabolism, Biomechanics, Notch width
Depositing User : Symplectic Elements
Date Deposited : 21 Feb 2017 09:20
Last Modified : 31 Oct 2017 19:08
URI: http://epubs.surrey.ac.uk/id/eprint/813571

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