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Chondrocyte secretome: a source of novel insights and exploratory biomarkers of osteoarthritis

Sanchez, C, Bay-Jensen, A-C, Pap, T, Dvir-Ginzberg, M, Quasnichka, Helen, Barrett-Jolley, R, Mobasheri, Ali and Henrotin, Y (2017) Chondrocyte secretome: a source of novel insights and exploratory biomarkers of osteoarthritis Osteoarthritis and Cartilage.

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Abstract

The extracellular matrix (ECM) of articular cartilage is comprised of complex networks of proteins and glycoproteins, all of which are expressed by its resident cell, the chondrocyte. Cartilage is a unique tissue given its complexity and ability to resist repeated load and deformation. The mechanisms by which articular cartilage maintains its integrity throughout our lifetime is not fully understood, however there are numerous regulatory pathways known to govern ECM turnover in response to mechanical stimuli. To further our understanding of this field, we envision that proteomic analysis of the secretome will provide information on how the chondrocyte remodels the surrounding ECM in response to load, in addition to providing information on the metabolic state of the cell. In this review, we attempt to summarize the recent mass spectrometry-based proteomic discoveries in healthy and diseased cartilage and chondrocytes, to facilitate the discovery of novel biomarkers linked to degenerative pathologies, such as osteoarthritis (OA).

Item Type: Article
Subjects : Veterinary Medicine
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
NameEmailORCID
Sanchez, CUNSPECIFIEDUNSPECIFIED
Bay-Jensen, A-CUNSPECIFIEDUNSPECIFIED
Pap, TUNSPECIFIEDUNSPECIFIED
Dvir-Ginzberg, MUNSPECIFIEDUNSPECIFIED
Quasnichka, Helenh.quasnichka@surrey.ac.ukUNSPECIFIED
Barrett-Jolley, RUNSPECIFIEDUNSPECIFIED
Mobasheri, Alia.mobasheri@surrey.ac.ukUNSPECIFIED
Henrotin, YUNSPECIFIEDUNSPECIFIED
Date : 20 February 2017
Identification Number : 10.1016/j.joca.2017.02.797
Copyright Disclaimer : © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords : Cartilage, Chondrocyte, Osteoarthritis, Biomarker, Proteomics, Secretome, Extracellular matrix (ECM)
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 16 Feb 2017 11:50
Last Modified : 19 Jul 2017 10:50
URI: http://epubs.surrey.ac.uk/id/eprint/813567

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