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Two-Dimensional, pH-Responsive Oligoglycine-Based Nanocarriers

Garriga, R, Jurewicz, I, Romero, E, Jarne, C, Cebolla, VL, Dalton, AB and Munoz, E (2016) Two-Dimensional, pH-Responsive Oligoglycine-Based Nanocarriers ACS APPLIED MATERIALS & INTERFACES, 8 (3). pp. 1913-1921.

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Abstract

The nanocarrier capabilities of atomically smooth two-dimensional sheets of a biantennary oligoglycine peptide C8H16(−CH2–NH–Gly5)2 (also called tectomers) are demonstrated. We show that the pH-controlled, rapid, and reversible assembly and disassembly of oligoglycine can be effectively used for controlled loading and release of the anticancer drug and fluorescent probe coralyne. The calculated partition coefficient in water is of the same order of magnitude or higher when compared to other nanocarriers such as liposomes and micelles, signifying the tectomer’s impressive loading capabilities. Moreover, the loading of guest molecules in tectomers facilitates the protection from rapid photochemically induced degradation. Such efficient, pH-sensitive, stable, and biocompatible nanocarriers are extremely attractive for biosensing, therapeutic, and theranostic applications. Additionally, our results suggest that these planar self-assembled materials can also act as phase-transfer vehicles for hydrophobic cargoes further broadening their biomedical and technological applications.

Item Type: Article
Subjects : Physics
Divisions : Faculty of Engineering and Physical Sciences > Physics
Authors :
AuthorsEmailORCID
Garriga, RUNSPECIFIEDUNSPECIFIED
Jurewicz, IUNSPECIFIEDUNSPECIFIED
Romero, EUNSPECIFIEDUNSPECIFIED
Jarne, CUNSPECIFIEDUNSPECIFIED
Cebolla, VLUNSPECIFIEDUNSPECIFIED
Dalton, ABUNSPECIFIEDUNSPECIFIED
Munoz, EUNSPECIFIEDUNSPECIFIED
Date : 27 January 2016
Identification Number : https://doi.org/10.1021/acsami.5b10077
Copyright Disclaimer : Copyright © 2016 American Chemical Society
Uncontrolled Keywords : Science & Technology, Technology, Nanoscience & Nanotechnology, Materials Science, Multidisciplinary, Science & Technology - Other Topics, Materials Science, oligoglycine, tectomers, nanocarriers, pH-controlled release, fluorescence, DRUG-DELIVERY-SYSTEMS, CARBON NANOTUBES, TOPOISOMERASE-I, MULTIFUNCTIONAL NANOCARRIERS, ALKALOID CORALYNE, GENERAL DETECTION, SELF-ASSOCIATION, NANOPARTICLES, AGENTS, FLUORESCENCE
Related URLs :
Additional Information : Full text not available from this repository.
Depositing User : Symplectic Elements
Date Deposited : 15 Feb 2017 14:37
Last Modified : 15 Feb 2017 14:37
URI: http://epubs.surrey.ac.uk/id/eprint/813555

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