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Associations between exhaust and non-exhaust particulate matter and stroke incidence by stroke subtype in South London

Crichton, S, Barratt, B, Spiridou, A, Hoang, U, Liang, SF, Kovalchuk, Y, Beevers, SD, Kelly, FJ, Delaney, B and Wolfe, CD (2016) Associations between exhaust and non-exhaust particulate matter and stroke incidence by stroke subtype in South London Science of the Total Environment, 568. pp. 278-284.

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Abstract

Background Airborne particulate matter (PM) consists of particles from diverse sources, including vehicle exhausts. Associations between short-term PM changes and stroke incidence have been shown. Cumulative exposures over several months, or years, are less well studied; few studies examined ischaemic subtypes or PM source. Aims This study combines a high resolution urban air quality model with a population-based stroke register to explore associations between long-term exposure to PM and stroke incidence. Method Data from the South London Stroke Register from 2005–2012 were included. Poisson regression explored association between stroke incidence and long-term (averaged across the study period) exposure to PM2.5(PM < 2.5 μm diameter) and PM10(PM < 10 μm), nitric oxide, nitrogen dioxide, nitrogen oxides and ozone, at the output area level (average population = 309). Estimates were standardised for age and sex and adjusted for socio-economic deprivation. Models were stratified for ischaemic and haemorrhagic strokes and further broken down by Oxford Community Stroke Project classification and Trial of ORG 10172 in Acute Stroke Treatment (TOAST) classification. Results 1800 strokes were recorded (incidence = 42.6/100,000 person-years). No associations were observed between PM and overall ischaemic or haemorrhagic incidence. For an interquartile range increase in PM2.5, there was a 23% increase in incidence (Incidence rate ratio = 1.23 (95%CI: 1.03–1.44)) of total anterior circulation infarcts (TACI) and 20% increase for PM2.5 from exhausts (1.20(1.01–1.41)). There were similar associations with PM10, overall (1.21(1.01–1.44)) and from exhausts (1.20(1.01–1.41)). TACI incidence was not associated with non-exhaust sources. There were no associations with other stroke subtypes or pollutants. Conclusion Outdoor air pollution, particularly that arising from vehicle exhausts, may increase risk of TACI but not other stroke subtypes.

Item Type: Article
Subjects : Biosciences
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
AuthorsEmailORCID
Crichton, SUNSPECIFIEDUNSPECIFIED
Barratt, BUNSPECIFIEDUNSPECIFIED
Spiridou, AUNSPECIFIEDUNSPECIFIED
Hoang, UUNSPECIFIEDUNSPECIFIED
Liang, SFUNSPECIFIEDUNSPECIFIED
Kovalchuk, YUNSPECIFIEDUNSPECIFIED
Beevers, SDUNSPECIFIEDUNSPECIFIED
Kelly, FJUNSPECIFIEDUNSPECIFIED
Delaney, BUNSPECIFIEDUNSPECIFIED
Wolfe, CDUNSPECIFIEDUNSPECIFIED
Date : 15 October 2016
Identification Number : https://doi.org/10.1016/j.scitotenv.2016.06.009
Copyright Disclaimer : © 2016 Elsevier B.V. All rights reserved
Uncontrolled Keywords : Stroke, Incidence, Air pollution
Depositing User : Symplectic Elements
Date Deposited : 03 Feb 2017 11:29
Last Modified : 03 Feb 2017 11:29
URI: http://epubs.surrey.ac.uk/id/eprint/813446

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