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Validation of a protein panel for the non-invasive detection of recurrent non-muscle invasive bladder cancer

Gogalic, S, Sauer, U, Doppler, S, Heinzel, A, Perco, P, Lukas, A, Simpson, Guy, Pandha, Hardev, Horvath, A and Preininger, C (2017) Validation of a protein panel for the non-invasive detection of recurrent non-muscle invasive bladder cancer Biomarkers.

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Abstract

Context: About 50–70% of patients with non-muscle invasive bladder cancer (NMIBC) experience relapse of disease. Objective: To establish a panel of protein biomarkers incorporated in a multiplexed microarray (BCa chip) and a classifier for diagnosing recurrent NMIBC. Materials and methods: Urine samples from 45 patients were tested. Diagnostic performance was evaluated by receiver operating characteristic (ROC) analysis. Results: A multi biomarker panel (ECadh, IL8, MMP9, EN2, VEGF, past recurrences, BCG therapies and stage at diagnosis) was identified yielding an area under the curve of 0.96. Discussion and conclusion: This biomarker panel represents a potential diagnostic tool for noninvasive diagnosis of recurrent NMIBC.

Item Type: Article
Subjects : Biosciences and Medicine
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Gogalic, SUNSPECIFIEDUNSPECIFIED
Sauer, UUNSPECIFIEDUNSPECIFIED
Doppler, SUNSPECIFIEDUNSPECIFIED
Heinzel, AUNSPECIFIEDUNSPECIFIED
Perco, PUNSPECIFIEDUNSPECIFIED
Lukas, AUNSPECIFIEDUNSPECIFIED
Simpson, GuyG.Simpson@surrey.ac.ukUNSPECIFIED
Pandha, HardevH.Pandha@surrey.ac.ukUNSPECIFIED
Horvath, AUNSPECIFIEDUNSPECIFIED
Preininger, CUNSPECIFIEDUNSPECIFIED
Date : 19 January 2017
Identification Number : 10.1080/1354750X.2016.1276628
Copyright Disclaimer : This is an Accepted Manuscript of an article published by Taylor & Francis in Biomarkers on 19 January 2017, available online: http://www.tandfonline.com/10.1080/1354750X.2016.1276628
Depositing User : Symplectic Elements
Date Deposited : 31 Jan 2017 14:53
Last Modified : 19 Jul 2017 08:52
URI: http://epubs.surrey.ac.uk/id/eprint/813402

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