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Phytochemical Investigations of Three Rhodocodon (Hyacinthaceae Sensu APG II) Species

Schwikkard, S, Alqahtani, A, Knirsch, W, Wetschnig, W, Jaksevicius, A, Opara, EI, Langat, Moses, Andriantiana, JL and Mulholland, Dulcie (2017) Phytochemical Investigations of Three Rhodocodon (Hyacinthaceae Sensu APG II) Species Journal of Natural Products, 80 (1). pp. 30-37.

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Abstract

The genus Rhodocodon (Hyacinthaceae sensu APG II) is endemic to Madagascar and its phytochemistry has not been described previously. The phytochemistry of three species in this genus has been investigated and eight compounds, including three bufadienolides (compounds 1, 4, and 5), a norlignan (2), and four homoisoflavonoids (compounds 3 and 6-8) have been isolated and identified. Compounds 1-3 and 6-8 have not been described previously. The COX-2 inhibitory activity of compound 6 and compound 7 acetate (compound 7A) were investigated on isolated colorectal cancer cells. Compounds 6 and 7A inhibited COX-2 by 10% and 8%, respectively, at a concentration of 12.5 M compared to 12% for 1 mM aspirin (the positive control).

Item Type: Article
Subjects : Chemistry
Divisions : Faculty of Engineering and Physical Sciences > Chemistry
Authors :
NameEmailORCID
Schwikkard, SUNSPECIFIEDUNSPECIFIED
Alqahtani, AUNSPECIFIEDUNSPECIFIED
Knirsch, WUNSPECIFIEDUNSPECIFIED
Wetschnig, WUNSPECIFIEDUNSPECIFIED
Jaksevicius, AUNSPECIFIEDUNSPECIFIED
Opara, EIUNSPECIFIEDUNSPECIFIED
Langat, MosesM.Langat@surrey.ac.ukUNSPECIFIED
Andriantiana, JLUNSPECIFIEDUNSPECIFIED
Mulholland, DulcieD.Mulholland@surrey.ac.ukUNSPECIFIED
Date : 4 January 2017
Identification Number : 10.1021/acs.jnatprod.6b00240
Copyright Disclaimer : Copyright 2017 American Chemical Society
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 25 Jan 2017 18:23
Last Modified : 07 Jul 2017 10:33
URI: http://epubs.surrey.ac.uk/id/eprint/813371

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