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Acridone alkaloids from Vepris verdoorniana (Excell & Mendonça) Mziray (Rutaceae)

Atangana, AF, Toze, FAA, Langat, Moses, Happi, EN, Meva’a Mbazea, LL, Mulholland, Dulcie, Waffo, AFK, Sewald, N and Wansi, JD (2017) Acridone alkaloids from Vepris verdoorniana (Excell & Mendonça) Mziray (Rutaceae) Phytochemistry Letters, 19. pp. 191-195.

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Abstract

Two new acridone alkaloids, verdoocridone A (1) and B (4), together with fifteen known compounds were isolated from methanol extracts of the roots and leaves of Vepris verdoorniana. The structures of all compounds were determined by comprehensive spectroscopic analyses (1D and 2D NMR, EI- and ESI– MS). The 13C NMR values of 1,2,3,5-tetramethoxy-N-methylacridone (2) and 5-methoxyaborinine (3) are also reported. The crude extracts and compounds (1-6) were tested for their antimicrobial activity. The test delivered moderate activities for crude extracts and compounds 1, 5 and 6 against the bacterium Staphylococcus aureus and the fungi Mucor meihei and Candida albicans with MIC values between 115 and 180mg/mL for extracts and between 21.3 and 29.4mM for compounds, compared to gentamycin with 0.2mM and nystatin with 5.2mM against both fungi. The determination of the radical scanvenging activity using 1,1-dephenyl-2-picrylhydrazyl (DPPH) assay gave moderate antioxidant values for all tested compounds, with IC50 between 0.29 and 0.41mM, compared to the standard 3-t-butyl-4- hydroxyanisole (BHA) displaying 0.03mM.

Item Type: Article
Subjects : Chemistry
Divisions : Faculty of Engineering and Physical Sciences > Chemistry
Authors :
NameEmailORCID
Atangana, AFUNSPECIFIEDUNSPECIFIED
Toze, FAAUNSPECIFIEDUNSPECIFIED
Langat, MosesM.Langat@surrey.ac.ukUNSPECIFIED
Happi, ENUNSPECIFIEDUNSPECIFIED
Meva’a Mbazea, LLUNSPECIFIEDUNSPECIFIED
Mulholland, DulcieD.Mulholland@surrey.ac.ukUNSPECIFIED
Waffo, AFKUNSPECIFIEDUNSPECIFIED
Sewald, NUNSPECIFIEDUNSPECIFIED
Wansi, JDUNSPECIFIEDUNSPECIFIED
Date : 11 January 2017
Identification Number : 10.1016/j.phytol.2017.01.001
Copyright Disclaimer : © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords : Vepris verdoorniana Rutaceae acridone alkaloids antimicrobial and antioxidant activities
Depositing User : Symplectic Elements
Date Deposited : 25 Jan 2017 17:54
Last Modified : 31 Oct 2017 19:04
URI: http://epubs.surrey.ac.uk/id/eprint/813369

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