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Designing a bio-inspired bio-mimetic in vitro system for the optimisation of ex vivo studies of pancreatic cancer

Totti, Styliani, Vernardis, SI, Meira, Lisiane, Pérez-Mancera, PA, Costello, E, Greenhalf, W, Palmer, D, Neoptolemos, J, Mantalaris, A and Velliou, Eirini (2017) Designing a bio-inspired bio-mimetic in vitro system for the optimisation of ex vivo studies of pancreatic cancer Drug Discovery Today, 22 (4). pp. 690-701.

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Abstract

Pancreatic cancer is one of the most aggressive and lethal human malignancies. Drug therapies and radiotherapy are used for treatment as adjuvants to surgery, but outcomes remain disappointing. Advances in tissue engineering point that three-dimensional cultures can reflect the in vivo tumour micro-environment and can guarantee a physiological distribution of oxygen, nutrients and drugs, therefore, being promising low cost tools for therapy development. In this work we review crucial elements, i.e., structural and environmental, that should be considered for an accurate design of an ex vivo platform for studies of pancreatic cancer. Furthermore, we propose environmental stress response biomarkers as platform readouts for the efficient control and further prediction of the pancreatic cancer response to the environmental and treatment input.

Item Type: Article
Subjects : Chemical & Process Engineering
Divisions : Faculty of Engineering and Physical Sciences > Chemical and Process Engineering
Authors :
NameEmailORCID
Totti, Stylianis.totti@surrey.ac.ukUNSPECIFIED
Vernardis, SIUNSPECIFIEDUNSPECIFIED
Meira, LisianeL.Meira@surrey.ac.ukUNSPECIFIED
Pérez-Mancera, PAUNSPECIFIEDUNSPECIFIED
Costello, EUNSPECIFIEDUNSPECIFIED
Greenhalf, WUNSPECIFIEDUNSPECIFIED
Palmer, DUNSPECIFIEDUNSPECIFIED
Neoptolemos, JUNSPECIFIEDUNSPECIFIED
Mantalaris, AUNSPECIFIEDUNSPECIFIED
Velliou, Eirinie.velliou@surrey.ac.ukUNSPECIFIED
Date : 30 January 2017
Identification Number : 10.1016/j.drudis.2017.01.012
Copyright Disclaimer : © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords : Pancreatic cancer, tissue engineering, 3D culture systems, stress biomarkers, environmental stress, hypoxia, metabolic stress, metabolomics
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 18 Jan 2017 11:22
Last Modified : 07 Jul 2017 10:51
URI: http://epubs.surrey.ac.uk/id/eprint/813320

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