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Perivascular cells and tissue engineering: current applications and untapped potential

Avolio, E, Alvino, VV, Ghorbel, MT and Campagnolo, Paola (2016) Perivascular cells and tissue engineering: current applications and untapped potential Pharmacology and Therapeutics, 171. pp. 83-92.

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Abstract

The recent development of tissue engineering provides exciting new perspectives for the replacement of failing organs and the repair of damaged tissues. Perivascular cells, including vascular smooth muscle cells, pericytes and other tissue specific populations residing around blood vessels, have been isolated from many organs and are known to participate to the in situ repair process and angiogenesis. Their potential has been harnessed for cell therapy of numerous pathologies; however, in this Review we will discuss the potential of perivascular cells in the development of tissue engineering solutions for healthcare. We will examine their application in the engineering of vascular grafts, cardiac patches and bone substitutes as well as other tissue engineering applications and we will focus on their extensive use in the vascularization of engineered constructs. Additionally, we will discuss the emerging potential of human pericytes for the development of efficient, vascularized and non-immunogenic engineered constructs.

Item Type: Article
Subjects : Biochemical Sciences
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Avolio, EUNSPECIFIEDUNSPECIFIED
Alvino, VVUNSPECIFIEDUNSPECIFIED
Ghorbel, MTUNSPECIFIEDUNSPECIFIED
Campagnolo, Paolap.campagnolo@surrey.ac.ukUNSPECIFIED
Date : 24 November 2016
Identification Number : 10.1016/j.pharmthera.2016.11.002
Copyright Disclaimer : © 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Uncontrolled Keywords : Biomaterials, pericytes, perivascular cells, tissue engineering, vascular graft, scaffold vascularization
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 11 Jan 2017 12:08
Last Modified : 12 Sep 2017 17:21
URI: http://epubs.surrey.ac.uk/id/eprint/813264

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