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A calix[4]arene derivative and its selective interaction with drugs (clofibric acid, diclofenac and aspirin)

de Namor, AFD, Al Nuaim, M, Villanueva Salas, JA, Bryant, S and Howlin, Brendan (2017) A calix[4]arene derivative and its selective interaction with drugs (clofibric acid, diclofenac and aspirin) European Journal of Pharmaceutical Sciences, 100. pp. 1-8.

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Abstract

The synthesis and characterisation of a partially substituted calix[4]arene, namely, 5,11,17,23- tetra-tert-butyl,25,27-bis[aminoethoxy] 26,28-dihydroxycalix[4]arene are reported. Its interaction with commonly used pharmaceuticals (clofibric acid, diclofenac and aspirin) was investigated by spectroscopic (1 H NMR and UV), electrochemical (conductance measurements) and thermal (titration calorimetry) techniques. It is concluded on the basis of the experimental work and molecular simulation studies that the receptor interacts selectively with these drugs. Preliminary studies on the selective extraction of these pharmaceuticals from water by the calix receptor are reported and the potential for a carrier mediated sensor based on this ligand for ‘on site’ monitoring of pharmaceuticals is discussed.

Item Type: Article
Subjects : Chemistry
Divisions : Faculty of Engineering and Physical Sciences > Chemistry
Authors :
NameEmailORCID
de Namor, AFD
Al Nuaim, M
Villanueva Salas, JA
Bryant, S
Howlin, BrendanB.Howlin@surrey.ac.uk
Date : 4 January 2017
Identification Number : 10.1016/j.ejps.2016.12.027
Copyright Disclaimer : © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Depositing User : Symplectic Elements
Date Deposited : 10 Jan 2017 10:12
Last Modified : 04 Jan 2018 02:08
URI: http://epubs.surrey.ac.uk/id/eprint/813243

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