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Circadian Rhythm and Sleep Disruption: Causes Metabolic Consequences and Countermeasures

Potter, GDM, Skene, DJ, Arendt, J, Cade, JE, Grant, PJ and Hardie, LJ (2016) Circadian Rhythm and Sleep Disruption: Causes Metabolic Consequences and Countermeasures Endocrine Reviews, 37 (6).

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Abstract

Circadian (∼24-hour) timing systems pervade all kingdoms of life and temporally optimize behavior and physiology in humans. Relatively recent changes to our environments, such as the introduction of artificial lighting, can disorganize the circadian system, from the level of the molecular clocks that regulate the timing of cellular activities to the level of synchronization between our daily cycles of behavior and the solar day. Sleep/wake cycles are intertwined with the circadian system, and global trends indicate that these, too, are increasingly subject to disruption. A large proportion of the world's population is at increased risk of environmentally driven circadian rhythm and sleep disruption, and a minority of individuals are also genetically predisposed to circadian misalignment and sleep disorders. The consequences of disruption to the circadian system and sleep are profound and include myriad metabolic ramifications, some of which may be compounded by adverse effects on dietary choices. If not addressed, the deleterious effects of such disruption will continue to cause widespread health problems; therefore, implementation of the numerous behavioral and pharmaceutical interventions that can help restore circadian system alignment and enhance sleep will be important.

Item Type: Article
Subjects : Biosciences and Medicine
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
AuthorsEmailORCID
Potter, GDMUNSPECIFIEDUNSPECIFIED
Skene, DJUNSPECIFIEDUNSPECIFIED
Arendt, JUNSPECIFIEDUNSPECIFIED
Cade, JEUNSPECIFIEDUNSPECIFIED
Grant, PJUNSPECIFIEDUNSPECIFIED
Hardie, LJUNSPECIFIEDUNSPECIFIED
Date : 20 October 2016
Identification Number : https://doi.org/10.1210/er.2016-1083
Copyright Disclaimer : This article has been published under the terms of the Creative Commons Attribution License (CC-BY; https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s).
Depositing User : Symplectic Elements
Date Deposited : 06 Jan 2017 14:55
Last Modified : 06 Jan 2017 14:55
URI: http://epubs.surrey.ac.uk/id/eprint/813222

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