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Ascaris phylogeny based on multiple whole mtDNA genomes

Nejsum, P, Hawash, MBF, Betson, Martha, Stothard, JR, Gasser, RB and Andersen, LO (2016) Ascaris phylogeny based on multiple whole mtDNA genomes Infection, Genetics and Evolution, 48. pp. 4-9.

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Abstract

Ascaris lumbricoides and A. suum are two parasitic nematodes infecting humans and pigs, respectively. There has been considerable debate as to whether Ascaris in the two hosts should be considered a single or two separate species. Previous studies identified at least three major clusters (A, B and C) of human and pig Ascaris based on partial cox1 sequences. In the present study, we selected major haplotypes from these different clusters to characterize their whole mitochondrial genomes for phylogenetic analysis. We also undertook coalescent simulations to investigate the evolutionary history of the different Ascaris haplotypes. The topology of the phylogenetic tree based on complete mitochondrial genomic sequences was found to be similar to partial cox1 sequencing, but the support at internal nodes was higher in the former. Coalescent simulations suggested the presence of at least two divergence events: the first one occurring early in the Neolithic period which resulted in a differentiated population of Ascaris in pigs (cluster C), the second occurring more recently (~900 generations ago), resulting in clusters A and B which might have been spread worldwide by human activities.

Item Type: Article
Subjects : Veterinary Medicine
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
NameEmailORCID
Nejsum, PUNSPECIFIEDUNSPECIFIED
Hawash, MBFUNSPECIFIEDUNSPECIFIED
Betson, Martham.betson@surrey.ac.ukUNSPECIFIED
Stothard, JRUNSPECIFIEDUNSPECIFIED
Gasser, RBUNSPECIFIEDUNSPECIFIED
Andersen, LOUNSPECIFIEDUNSPECIFIED
Date : 7 December 2016
Identification Number : 10.1016/j.meegid.2016.12.003
Copyright Disclaimer : © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords : Ascaris, mitochondrial genomes, human, pig, phylogeny, soil transmitted helminth
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 22 Dec 2016 09:57
Last Modified : 18 Jul 2017 15:21
URI: http://epubs.surrey.ac.uk/id/eprint/813168

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