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Association between vitamin D supplementation and severity of tuberculosis in wild boar and red deer

Risco, D, Salguero Bodes, FJ, Cerrato, R, Gutierrez-Merinod, J, Lanham-New, S, Barquero-Pérez, O, Hermoso de Mendoza, J and Fernández-Llario, P (2016) Association between vitamin D supplementation and severity of tuberculosis in wild boar and red deer Research in Veterinary Science, 108. pp. 116-119.

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Abstract

Tuberculosis (TB) is a chronic disease affecting humans and other mammal species. Severity of TB caused by Mycobacterium tuberculosis in humans seems to be influenced by nutritional factors like vitamin D3 intake. However, this relationship has been scarcely studied in cattle and other mammals infected with Mycobacterium bovis. The aim of this work was to assess if wildlife reservoirs of M. bovis show different levels of TB severity depending on the level of vitamin D found in serum after supplementation with vitamin D3. Forty hunted wildlife mammals were included in this study: 20 wild boar and 20 red deer. Ten wild boar and ten red deer had been supplemented with a vitamin D3-enriched food, whereas the remaining animals had received no supplementation. TB diagnosis was carried out in each animal based on microbiological isolation of M. bovis. Animals infected with M. bovis were then classified as animals with localized or generalized TB depending on the location and dissemination of the lesions. Furthermore, serum levels of vitamin D2 and D3 were determined in each animal to evaluate differences not only between supplemented and non-supplemented animals but also between those with localized and generalized TB. Levels of vitamin D3 found in both, supplemented wild boar and red deer, were significantly higher than those found in the non-supplemented animals. Interestingly, higher levels of vitamin D3 were observed in animals suffering localized TB when compared to animals with generalized TB suggesting that vitamin D3 concentration correlates negatively with TB severity in these wildlife reservoirs.

Item Type: Article
Subjects : Veterinary Science
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
NameEmailORCID
Risco, DUNSPECIFIEDUNSPECIFIED
Salguero Bodes, FJUNSPECIFIEDUNSPECIFIED
Cerrato, RUNSPECIFIEDUNSPECIFIED
Gutierrez-Merinod, JUNSPECIFIEDUNSPECIFIED
Lanham-New, SUNSPECIFIEDUNSPECIFIED
Barquero-Pérez, OUNSPECIFIEDUNSPECIFIED
Hermoso de Mendoza, JUNSPECIFIEDUNSPECIFIED
Fernández-Llario, PUNSPECIFIEDUNSPECIFIED
Date : October 2016
Identification Number : 10.1016/j.rvsc.2016.08.003
Copyright Disclaimer : © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords : Red deer, Tuberculosis, Vitamin D, Wild boar
Depositing User : Symplectic Elements
Date Deposited : 28 Oct 2016 13:45
Last Modified : 24 Aug 2017 02:08
URI: http://epubs.surrey.ac.uk/id/eprint/812667

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