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Cohort profile: the Baependi Heart Study--a family-based, highly admixed cohort study in a rural Brazilian town

Egan, KJ, von Schantz, M, Negrão, AB, Santos, HC, Horimoto, ARVR, Duarte, NE, Gonçalves, GC, Soler, JMP, de Andrade, M, Lorenzi-Filho, G , Vallada, H, Taporoski, TP, Pedrazzoli, M, Azambuja, AP, de Oliveira, CM, Alvim, RO, Krieger, JE and Pereira, AC (2016) Cohort profile: the Baependi Heart Study--a family-based, highly admixed cohort study in a rural Brazilian town BMJ Open, 6 (10), e011598.

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Abstract

Purpose Cardiovascular disease (CVD) is a major challenge to global health. The same epidemiological transition scenario is replayed as countries develop, but with variations based on environment, culture and ethnic mixture. The Baependi Heart Study was set up in 2005 to develop a longitudinal family-based cohort study that reflects on some of the genetic and lifestyle-related peculiarities of the Brazilian populations, in order to evaluate genetic and environmental influences on CVD risk factor traits. Participants Probands were recruited in Baependi, a small rural town in the state of Minas Gerais, Brazil, following by first-degree and then increasingly more distant relatives. The first follow-up wave took place in 2010, and the second in 2016. At baseline, the study evaluated 1691 individuals across 95 families. Cross-sectional data have been collected for 2239 participants. Findings to date Environmental and lifestyle factors and measures relevant to cardiovascular health have been reported. Having expanded beyond cardiovascular health outcomes, the phenotype datasets now include genetics, biochemistry, anthropometry, mental health, sleep and circadian rhythms. Many of these have yielded heritability estimates, and a shared genetic background of anxiety and depression has recently been published. In spite of universal access to electricity, the population has been found to be strongly shifted towards morningness compared with metropolitan areas. Future plans A new follow-up, marking 10 years of the study, is ongoing in 2016, in which data are collected as in 2010 (with the exception of the neuropsychiatric protocol). In addition to this, a novel questionnaire package collecting information about intelligence, personality and spirituality is being planned. The data set on circadian rhythms and sleep will be amended through additional questionnaires, actimetry, home sleep EEG recording and dim light melatonin onset (DLMO) analysis. Finally, the anthropometric measures will be expanded by adding three-dimensional facial photography, voice recording and anatomical brain MRI.

Item Type: Article
Subjects : Biosciences and Medicine
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Egan, KJUNSPECIFIEDUNSPECIFIED
von Schantz, MUNSPECIFIEDUNSPECIFIED
Negrão, ABUNSPECIFIEDUNSPECIFIED
Santos, HCUNSPECIFIEDUNSPECIFIED
Horimoto, ARVRUNSPECIFIEDUNSPECIFIED
Duarte, NEUNSPECIFIEDUNSPECIFIED
Gonçalves, GCUNSPECIFIEDUNSPECIFIED
Soler, JMPUNSPECIFIEDUNSPECIFIED
de Andrade, MUNSPECIFIEDUNSPECIFIED
Lorenzi-Filho, GUNSPECIFIEDUNSPECIFIED
Vallada, HUNSPECIFIEDUNSPECIFIED
Taporoski, TPUNSPECIFIEDUNSPECIFIED
Pedrazzoli, MUNSPECIFIEDUNSPECIFIED
Azambuja, APUNSPECIFIEDUNSPECIFIED
de Oliveira, CMUNSPECIFIEDUNSPECIFIED
Alvim, ROUNSPECIFIEDUNSPECIFIED
Krieger, JEUNSPECIFIEDUNSPECIFIED
Pereira, ACUNSPECIFIEDUNSPECIFIED
Date : 21 October 2016
Identification Number : 10.1136/bmjopen-2016-011598
Copyright Disclaimer : This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Depositing User : Symplectic Elements
Date Deposited : 25 Oct 2016 11:32
Last Modified : 31 Oct 2017 18:51
URI: http://epubs.surrey.ac.uk/id/eprint/812590

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