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Gestational and lactational exposure to low-dose bisphenol A increases Th17 cells in mice offspring

Luo, S, Li, Y, Li, Y, Zhu, Q, Jiang, J, Wu, C and Shen, T (2016) Gestational and lactational exposure to low-dose bisphenol A increases Th17 cells in mice offspring Environmental Toxicology and Pharmacology, 47. pp. 149-158.

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Abstract

Increasing evidence demonstrates that perinatal exposure to Bisphenol A (BPA) can cause immune disorders throughout the life span. However, the biological basis for these immune disorders is poorly understood and the effects of exposure to BPA on Th17 development are unknown. The present study sought to characterize alterations of Th17 cells in childhood and adulthood following gestational and lactational exposure to environmentally relevant low-dose of BPA and the underlying mechanisms. Pregnant dams were exposed to BPA (10, 100 or 1000 nM) via drinking water from gestational day (GD) 0 to postnatal day (PND) 21. At PNDs 21 and 42, offspring mice were anesthetized, blood was obtained for cytokine assay and spleens were collected for Th17 cell frequency and RORγt mRNA expression analysis. Perinatal exposure to low-dose BPA resulted in a dose-dependent and gender-specific persistent rise in Th17 cells accompanied by an increase of RORγt mRNA expression in the offsprings. The contents of major Th17 cell-derived cytokines (IL-17 and IL-21) and those essential for Th17 cell differentiation (IL-6 and IL-23) were also increased compared to those in controls. These changes were more pronounced in female than in male offsprings. However, perinatal exposure to low-dose BPA had little effect on serum TGF-β, another key regulator for Th17 cell development. Our results suggest that gestational and lactational exposure to a low-dose of BPA can affect Th17 cell development via an action on its transcription factor and the regulatory cytokines. These findings provide novel insight into sustained immune disorders by BPA exposure during development.

Item Type: Article
Subjects : Biosciences
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Biochemical Sciences
Authors :
NameEmailORCID
Luo, SUNSPECIFIEDUNSPECIFIED
Li, YUNSPECIFIEDUNSPECIFIED
Li, YUNSPECIFIEDUNSPECIFIED
Zhu, QUNSPECIFIEDUNSPECIFIED
Jiang, JUNSPECIFIEDUNSPECIFIED
Wu, CUNSPECIFIEDUNSPECIFIED
Shen, TUNSPECIFIEDUNSPECIFIED
Date : October 2016
Identification Number : 10.1016/j.etap.2016.09.017
Copyright Disclaimer : © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords : Bisphenol A, Cytokine, Maternal exposure, RORγt, Th17 cells
Depositing User : Symplectic Elements
Date Deposited : 24 Oct 2016 15:19
Last Modified : 26 Sep 2017 02:08
URI: http://epubs.surrey.ac.uk/id/eprint/812576

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