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Selenoprotein Gene Nomenclature

Gladyshev, VN, Arnér, ES, Berry, MJ, Brigelius-Flohé, R, Bruford, EA, Burk, RF, Carlson, BA, Castellano, S, Chavatte, L, Conrad, M, Copeland, PR, Diamond, AM, Driscoll, DM, Ferreiro, A, Flohé, L, Green, FR, Guigó, R, Handy, DE, Hatfield, DL, Hesketh, J, Hoffmann, PR, Holmgren, A, Hondal, RJ, Howard, MT, Huang, K, Kim, HY, Kim, IY, Köhrle, J, Krol, A, Kryukov, GV, Lee, BJ, Lee, BC, Lei, XG, Liu, Q, Lescure, A, Lobanov, AV, Loscalzo, J, Maiorino, M, Mariotti, M, Prabhu, KS, Rayman, MP, Rozovsky, S, Salinas, G, Schmidt, EE, Schomburg, L, Schweizer, U, Simonović, M, Sunde, RA, Tsuji, PA, Tweedie, S, Ursini, F, Whanger, PD and Zhang, Y (2016) Selenoprotein Gene Nomenclature Journal of Biological Chemistry.

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Abstract

The human genome contains 25 genes coding for selenocysteine-containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis. Selenoprotein enzymes with known functions are designated according to these functions: TXNRD1, TXNRD2, and TXNRD3 (thioredoxin reductases), GPX1, GPX2, GPX3, GPX4 and GPX6 (glutathione peroxidases), DIO1, DIO2, and DIO3 (iodothyronine deiodinases), MSRB1 (methionine-R-sulfoxide reductase 1) and SEPHS2 (selenophosphate synthetase 2). Selenoproteins without known functions have traditionally been denoted by SEL or SEP symbols. However, these symbols are sometimes ambiguous and conflict with the approved nomenclature for several other genes. Therefore, there is a need to implement a rational and coherent nomenclature system for selenoprotein-encoding genes. Our solution is to use the root symbol SELENO followed by a letter. This nomenclature applies to SELENOF (selenoprotein F, the 15 kDa selenoprotein, SEP15), SELENOH (selenoprotein H, SELH, C11orf31), SELENOI (selenoprotein I, SELI, EPT1), SELENOK (selenoprotein K, SELK), SELENOM (selenoprotein M, SELM), SELENON (selenoprotein N, SEPN1, SELN), SELENOO (selenoprotein O, SELO), SELENOP (selenoprotein P, SeP, SEPP1, SELP), SELENOS (selenoprotein S, SELS, SEPS1, VIMP), SELENOT (selenoprotein T, SELT), SELENOV (selenoprotein V, SELV) and SELENOW (selenoprotein W, SELW, SEPW1). This system, approved by the HUGO Gene Nomenclature Committee, also resolves conflicting, missing and ambiguous designations for selenoprotein genes and is applicable to selenoproteins across vertebrates.

Item Type: Article
Subjects : Medical Science
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Nutritional Sciences
Authors :
AuthorsEmailORCID
Gladyshev, VNUNSPECIFIEDUNSPECIFIED
Arnér, ESUNSPECIFIEDUNSPECIFIED
Berry, MJUNSPECIFIEDUNSPECIFIED
Brigelius-Flohé, RUNSPECIFIEDUNSPECIFIED
Bruford, EAUNSPECIFIEDUNSPECIFIED
Burk, RFUNSPECIFIEDUNSPECIFIED
Carlson, BAUNSPECIFIEDUNSPECIFIED
Castellano, SUNSPECIFIEDUNSPECIFIED
Chavatte, LUNSPECIFIEDUNSPECIFIED
Conrad, MUNSPECIFIEDUNSPECIFIED
Copeland, PRUNSPECIFIEDUNSPECIFIED
Diamond, AMUNSPECIFIEDUNSPECIFIED
Driscoll, DMUNSPECIFIEDUNSPECIFIED
Ferreiro, AUNSPECIFIEDUNSPECIFIED
Flohé, LUNSPECIFIEDUNSPECIFIED
Green, FRUNSPECIFIEDUNSPECIFIED
Guigó, RUNSPECIFIEDUNSPECIFIED
Handy, DEUNSPECIFIEDUNSPECIFIED
Hatfield, DLUNSPECIFIEDUNSPECIFIED
Hesketh, JUNSPECIFIEDUNSPECIFIED
Hoffmann, PRUNSPECIFIEDUNSPECIFIED
Holmgren, AUNSPECIFIEDUNSPECIFIED
Hondal, RJUNSPECIFIEDUNSPECIFIED
Howard, MTUNSPECIFIEDUNSPECIFIED
Huang, KUNSPECIFIEDUNSPECIFIED
Kim, HYUNSPECIFIEDUNSPECIFIED
Kim, IYUNSPECIFIEDUNSPECIFIED
Köhrle, JUNSPECIFIEDUNSPECIFIED
Krol, AUNSPECIFIEDUNSPECIFIED
Kryukov, GVUNSPECIFIEDUNSPECIFIED
Lee, BJUNSPECIFIEDUNSPECIFIED
Lee, BCUNSPECIFIEDUNSPECIFIED
Lei, XGUNSPECIFIEDUNSPECIFIED
Liu, QUNSPECIFIEDUNSPECIFIED
Lescure, AUNSPECIFIEDUNSPECIFIED
Lobanov, AVUNSPECIFIEDUNSPECIFIED
Loscalzo, JUNSPECIFIEDUNSPECIFIED
Maiorino, MUNSPECIFIEDUNSPECIFIED
Mariotti, MUNSPECIFIEDUNSPECIFIED
Prabhu, KSUNSPECIFIEDUNSPECIFIED
Rayman, MPUNSPECIFIEDUNSPECIFIED
Rozovsky, SUNSPECIFIEDUNSPECIFIED
Salinas, GUNSPECIFIEDUNSPECIFIED
Schmidt, EEUNSPECIFIEDUNSPECIFIED
Schomburg, LUNSPECIFIEDUNSPECIFIED
Schweizer, UUNSPECIFIEDUNSPECIFIED
Simonović, MUNSPECIFIEDUNSPECIFIED
Sunde, RAUNSPECIFIEDUNSPECIFIED
Tsuji, PAUNSPECIFIEDUNSPECIFIED
Tweedie, SUNSPECIFIEDUNSPECIFIED
Ursini, FUNSPECIFIEDUNSPECIFIED
Whanger, PDUNSPECIFIEDUNSPECIFIED
Zhang, YUNSPECIFIEDUNSPECIFIED
Date : 19 September 2016
Identification Number : https://doi.org/10.1074/jbc.M116.756155
Copyright Disclaimer : Copyright © 2016, The American Society for Biochemistry and Molecular Biology
Uncontrolled Keywords : selenoprotein, structure-function, nomenclature, selenocysteine, selenium, genomics
Depositing User : Symplectic Elements
Date Deposited : 24 Oct 2016 12:00
Last Modified : 24 Jan 2017 11:17
URI: http://epubs.surrey.ac.uk/id/eprint/812566

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