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Selenoprotein Gene Nomenclature

Gladyshev, VN, Arnér, ES, Berry, MJ, Brigelius-Flohé, R, Bruford, EA, Burk, RF, Carlson, BA, Castellano, S, Chavatte, L, Conrad, M , Copeland, PR, Diamond, AM, Driscoll, DM, Ferreiro, A, Flohé, L, Green, FR, Guigó, R, Handy, DE, Hatfield, DL, Hesketh, J, Hoffmann, PR, Holmgren, A, Hondal, RJ, Howard, MT, Huang, K, Kim, HY, Kim, IY, Köhrle, J, Krol, A, Kryukov, GV, Lee, BJ, Lee, BC, Lei, XG, Liu, Q, Lescure, A, Lobanov, AV, Loscalzo, J, Maiorino, M, Mariotti, M, Prabhu, KS, Rayman, MP, Rozovsky, S, Salinas, G, Schmidt, EE, Schomburg, L, Schweizer, U, Simonović, M, Sunde, RA, Tsuji, PA, Tweedie, S, Ursini, F, Whanger, PD and Zhang, Y (2016) Selenoprotein Gene Nomenclature Journal of Biological Chemistry.

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The human genome contains 25 genes coding for selenocysteine-containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis. Selenoprotein enzymes with known functions are designated according to these functions: TXNRD1, TXNRD2, and TXNRD3 (thioredoxin reductases), GPX1, GPX2, GPX3, GPX4 and GPX6 (glutathione peroxidases), DIO1, DIO2, and DIO3 (iodothyronine deiodinases), MSRB1 (methionine-R-sulfoxide reductase 1) and SEPHS2 (selenophosphate synthetase 2). Selenoproteins without known functions have traditionally been denoted by SEL or SEP symbols. However, these symbols are sometimes ambiguous and conflict with the approved nomenclature for several other genes. Therefore, there is a need to implement a rational and coherent nomenclature system for selenoprotein-encoding genes. Our solution is to use the root symbol SELENO followed by a letter. This nomenclature applies to SELENOF (selenoprotein F, the 15 kDa selenoprotein, SEP15), SELENOH (selenoprotein H, SELH, C11orf31), SELENOI (selenoprotein I, SELI, EPT1), SELENOK (selenoprotein K, SELK), SELENOM (selenoprotein M, SELM), SELENON (selenoprotein N, SEPN1, SELN), SELENOO (selenoprotein O, SELO), SELENOP (selenoprotein P, SeP, SEPP1, SELP), SELENOS (selenoprotein S, SELS, SEPS1, VIMP), SELENOT (selenoprotein T, SELT), SELENOV (selenoprotein V, SELV) and SELENOW (selenoprotein W, SELW, SEPW1). This system, approved by the HUGO Gene Nomenclature Committee, also resolves conflicting, missing and ambiguous designations for selenoprotein genes and is applicable to selenoproteins across vertebrates.

Item Type: Article
Subjects : Medical Science
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Nutritional Sciences
Authors :
Gladyshev, VN
Arnér, ES
Berry, MJ
Brigelius-Flohé, R
Bruford, EA
Burk, RF
Carlson, BA
Castellano, S
Chavatte, L
Conrad, M
Copeland, PR
Diamond, AM
Driscoll, DM
Ferreiro, A
Flohé, L
Green, FR
Guigó, R
Handy, DE
Hatfield, DL
Hesketh, J
Hoffmann, PR
Holmgren, A
Hondal, RJ
Howard, MT
Huang, K
Kim, HY
Kim, IY
Köhrle, J
Krol, A
Kryukov, GV
Lee, BJ
Lee, BC
Lei, XG
Liu, Q
Lescure, A
Lobanov, AV
Loscalzo, J
Maiorino, M
Mariotti, M
Prabhu, KS
Rayman, MP
Rozovsky, S
Salinas, G
Schmidt, EE
Schomburg, L
Schweizer, U
Simonović, M
Sunde, RA
Tsuji, PA
Tweedie, S
Ursini, F
Whanger, PD
Zhang, Y
Date : 19 September 2016
DOI : 10.1074/jbc.M116.756155
Copyright Disclaimer : Copyright © 2016, The American Society for Biochemistry and Molecular Biology
Uncontrolled Keywords : selenoprotein, structure-function, nomenclature, selenocysteine, selenium, genomics
Depositing User : Symplectic Elements
Date Deposited : 24 Oct 2016 12:00
Last Modified : 24 Jan 2017 11:17

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