Octreotide prevents hypoglycaemia in patients prone to post-prandial hypoglycaemia following bariatric surgery

Whyte, MB, Grove, G, Le Roux, CW, Patel, AG and Aylwin, SJB (2010) Octreotide prevents hypoglycaemia in patients prone to post-prandial hypoglycaemia following bariatric surgery In: 11th International Congress on Obesity, 2010-07-11 - 2010-07-15, Stockholm, Sweden.

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Abstract

Introduction: Recurrent symptomatic hyperinsulinaemic hypoglyca- emia has been increasingly recognised following Roux-en-Y gastric bypass (RYGB), is disabling and potentially dangerous to others. Dietary manipulation is frequently unsuccessful and patients have undergone surgical revision, restoration of gastric restriction, or par- tial pancreatectomy. Methods: Four patients with symptoms of post-prandial hypoglyca- emia following RYGB were evaluated. Patients underwent an extended oral glucose tolerance test (OGTT) receiving 75 g oral glu- cose with blood taken for insulin and glucose assays each 30 minutes for 240 minutes. The investigation was repeated after pre-adminis- tration of octreotide (100 mcg subcutaneous). Results: Patients were 40.3 ± 19.6 years old and between 1.5 and 7 years postoperative. Preoperative weight was 132.5 ± 14.4 kg, cur- rent weight 85.5 ± 24.6 kg. Glucose and insulin data from extended OGTT (mean ± SEM).are shown below. Symptomatic hypoglyca- emia occurred in all subjects at 150 minute. Peak insulin excursion at 60 minute was almost eliminated after octreotide administration. Conclusion: Reactive hypoglycaemia after RYGB can be provoked by an extended OGTT. Octreotide inhibits insulin release and in this study prevented hypoglycaemia after a single administration. It remains to be determined whether extended use might be of use in symptomatic patients.

Item Type:	Conference or Workshop Item (Conference Poster)
Subjects :	Nutrition
Divisions :	Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Nutritional Sciences
Authors :	Authors Email ORCID Whyte, MB UNSPECIFIED UNSPECIFIED Grove, G UNSPECIFIED UNSPECIFIED Le Roux, CW UNSPECIFIED UNSPECIFIED Patel, AG UNSPECIFIED UNSPECIFIED Aylwin, SJB UNSPECIFIED UNSPECIFIED
Date :	11 July 2010
Identification Number :	https://doi.org/10.1111/j.1467-789X.2010.00763_7.x
Copyright Disclaimer :	© 2010 The Authors. Journal Compilation © 2010 The International Association for the Study of Obesity. Copyright © 2010 John Wiley & Sons, Inc. All Rights Reserved.
Depositing User :	Symplectic Elements
Date Deposited :	21 Oct 2016 09:19
Last Modified :	21 Oct 2016 09:19
URI:	http://epubs.surrey.ac.uk/id/eprint/812537

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