A fall in serum prolactin level after a 2 hour rest predicts a normal MRI in patients using dopamine antagonist treatment

Whyte, MB (2010) A fall in serum prolactin level after a 2 hour rest predicts a normal MRI in patients using dopamine antagonist treatment In: Society for Endocrinology BES 2010, 2010-03-15 - 2010-03-18, Manchester, UK.

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Abstract

Introduction: Hyperprolactinaemia associated with antipsychotic drug use is a commonly encountered clinical problem, yet no decision-making tools exist to guide whether to scan the pituitary gland. Methods: A 10-year data series was reviewed of 246 patients who were evaluated for prolactin excess with a cannulated prolactin study. All patients had a prolactin drawn immediately following the insertion of a forearm cannula (P1) and a second sample drawn after 120 min bed rest (P2). Comparison was made between patients with a confirmed microprolactinoma (galactorhoea and/or oligomenorrohea with resting hyperprolactinaemia and microadenoma on MRI) against those on dopamine antagonists as well as normal controls. The presence of macroprolactin was excluded in all samples. Results: Sixteen patients out of 246 were on dopamine antagonists. In eight patients the prolactin normalised following discontinuation of the drug for at least 3 weeks. Conclusion: In our series, prolactin normalised after 2 weeks of cessation of dopamine antagonists, when treatment could safely be discontinued. A fall after 2 h rest predicted a normal MRI in patients continuing on dopamine antagonists.

Item Type:	Conference or Workshop Item (Conference Poster)
Subjects :	Nutrition
Divisions :	Faculty of Health and Medical Sciences > School of Biosciences and Medicine > Department of Nutritional Sciences
Authors :	Name Email ORCID Whyte, MB
Date :	15 March 2010
Copyright Disclaimer :	©2010 BioScientifica
Depositing User :	Symplectic Elements
Date Deposited :	20 Oct 2016 14:06
Last Modified :	31 Oct 2017 18:49
URI:	http://epubs.surrey.ac.uk/id/eprint/812532

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