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Effectiveness of seasonal influenza vaccine for adults and children in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2015/16 end-of-season results

Pebody, R, Warburton, F, Ellis, J, Andrews, N, Potts, A, Cottrell, S, Johnston, J, Reynolds, A, Gunson, R, Thompson, C, Galiano, M, Robertson, C, Byford, R, Gallagher, N, Sinnathamby, M, Yonova, I, Pathirannehelage, S, Donati, M, Moore, C, de Lusignan, S, McMenamin, J and Zambon, M (2016) Effectiveness of seasonal influenza vaccine for adults and children in preventing laboratory-confirmed influenza in primary care in the United Kingdom: 2015/16 end-of-season results Eurosurveillance, 21 (38).

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Abstract

The United Kingdom (UK) is in the third season of introducing universal paediatric influenza vaccination with a quadrivalent live attenuated influenza vaccine (LAIV). The 2015/16 season in the UK was initially dominated by influenza A(H1N1)pdm09 and then influenza of B/Victoria lineage, not contained in that season’s adult trivalent inactivated influenza vaccine (IIV). Overall adjusted end-of-season vaccine effectiveness (VE) was 52.4% (95% confidence interval (CI): 41.0–61.6) against influenza-confirmed primary care consultation, 54.5% (95% CI: 41.6–64.5) against influenza A(H1N1)pdm09 and 54.2% (95% CI: 33.1–68.6) against influenza B. In 2–17 year-olds, adjusted VE for LAIV was 57.6% (95% CI: 25.1 to 76.0) against any influenza, 81.4% (95% CI: 39.6–94.3) against influenza B and 41.5% (95% CI: −8.5 to 68.5) against influenza A(H1N1)pdm09. These estimates demonstrate moderate to good levels of protection, particularly against influenza B in children, but relatively less against influenza A(H1N1)pdm09. Despite lineage mismatch in the trivalent IIV, adults younger than 65 years were still protected against influenza B. These results provide reassurance for the UK to continue its influenza immunisation programme planned for 2016/17.

Item Type: Article
Subjects : Medical Science
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
AuthorsEmailORCID
Pebody, RUNSPECIFIEDUNSPECIFIED
Warburton, FUNSPECIFIEDUNSPECIFIED
Ellis, JUNSPECIFIEDUNSPECIFIED
Andrews, NUNSPECIFIEDUNSPECIFIED
Potts, AUNSPECIFIEDUNSPECIFIED
Cottrell, SUNSPECIFIEDUNSPECIFIED
Johnston, JUNSPECIFIEDUNSPECIFIED
Reynolds, AUNSPECIFIEDUNSPECIFIED
Gunson, RUNSPECIFIEDUNSPECIFIED
Thompson, CUNSPECIFIEDUNSPECIFIED
Galiano, MUNSPECIFIEDUNSPECIFIED
Robertson, CUNSPECIFIEDUNSPECIFIED
Byford, RUNSPECIFIEDUNSPECIFIED
Gallagher, NUNSPECIFIEDUNSPECIFIED
Sinnathamby, MUNSPECIFIEDUNSPECIFIED
Yonova, IUNSPECIFIEDUNSPECIFIED
Pathirannehelage, SUNSPECIFIEDUNSPECIFIED
Donati, MUNSPECIFIEDUNSPECIFIED
Moore, CUNSPECIFIEDUNSPECIFIED
de Lusignan, SUNSPECIFIEDUNSPECIFIED
McMenamin, JUNSPECIFIEDUNSPECIFIED
Zambon, MUNSPECIFIEDUNSPECIFIED
Date : 22 September 2016
Identification Number : https://doi.org/10.2807/1560-7917.ES.2016.21.38.30348
Copyright Disclaimer : This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made. This article is copyright of the authors, 2016.
Depositing User : Symplectic Elements
Date Deposited : 11 Oct 2016 09:19
Last Modified : 11 Oct 2016 09:19
URI: http://epubs.surrey.ac.uk/id/eprint/812365

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