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Detection of microcalcification clusters by 2D-mammography and narrow and wide angle digital breast tomosynthesis

Hadjipanteli, A, Elangovan, P, Looney, PT, Mackenzie, A, Wells, K, Wells, K, Dance, DR and Young, KC (2016) Detection of microcalcification clusters by 2D-mammography and narrow and wide angle digital breast tomosynthesis In: Medical Imaging 2016: Physics of Medical Imaging, 2016-02-28 - 2016-03-02, San Diego, California, United States.

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Abstract

The aim of this study was to compare the detection of microcalcification clusters by human observers in breast images using 2D-mammography and narrow (15°/15 projections) and wide (50°/25 projections) angle digital breast tomosynthesis (DBT). Simulated microcalcification clusters with a range of microcalcification diameters (125 μm-275 μm) were inserted into 6 cm thick simulated compressed breasts. Breast images were produced with and without inserted microcalcification clusters using a set of image modelling tools, which were developed to represent clinical imaging by mammography and tomosynthesis. Commercially available software was used for image processing and image reconstruction. The images were then used in a series of 4-alternative forced choice (4AFC) human observer experiments conducted for signal detection with the microcalcification clusters as targets. The minimum detectable calcification diameter was found for each imaging modality: (i) 2D-mammography: 164±5 μm (ii) narrow angle DBT: 210±5 μm, (iii) wide angle DBT: 255±4 μm. A statistically significant difference was found between the minimum detectable calcification diameters that can be detected by the three imaging modalities. Furthermore, it was found that there was not a statistically significant difference between the results of the five observers that participated in this study. In conclusion, this study presents a method that quantifies the threshold diameter required for microcalcification detection, using high resolution, realistic images with observers, for the comparison of DBT geometries with 2D-mammography. 2Dmammography can visualise smaller detail diameter than both DBT imaging modalities and narrow-angle DBT can visualise a smaller detail diameter than wide-angle DBT.

Item Type: Conference or Workshop Item (Conference Paper)
Subjects : Medical Science
Divisions : Faculty of Health and Medical Sciences
Authors :
AuthorsEmailORCID
Hadjipanteli, AUNSPECIFIEDUNSPECIFIED
Elangovan, PUNSPECIFIEDUNSPECIFIED
Looney, PTUNSPECIFIEDUNSPECIFIED
Mackenzie, AUNSPECIFIEDUNSPECIFIED
Wells, KUNSPECIFIEDUNSPECIFIED
Wells, KUNSPECIFIEDUNSPECIFIED
Dance, DRUNSPECIFIEDUNSPECIFIED
Young, KCUNSPECIFIEDUNSPECIFIED
Date : 22 March 2016
Identification Number : https://doi.org/10.1117/12.2217663
Copyright Disclaimer : Copyright 2016 Society of Photo Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Contributors :
ContributionNameEmailORCID
UNSPECIFIEDKontos, DUNSPECIFIEDUNSPECIFIED
UNSPECIFIEDFlohr, TGUNSPECIFIEDUNSPECIFIED
UNSPECIFIEDLo, JYUNSPECIFIEDUNSPECIFIED
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 20 Sep 2016 09:25
Last Modified : 20 Sep 2016 09:25
URI: http://epubs.surrey.ac.uk/id/eprint/812233

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