University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Exercise training reduces liver fat and increases rates of VLDL clearance, but not VLDL production in NAFLD

Shojaee-Moradie, F, Cuthbertson, DJ, Barrett, M, Jackson, NC, Herring, R, Thomas, EL, Bell, J, Kemp, GJ, Wright, J and Umpleby, M (2016) Exercise training reduces liver fat and increases rates of VLDL clearance, but not VLDL production in NAFLD Journal of Clinical Endocrinology and Metabolism.

[img]
Preview
Text
Exercise training reduces liver fat.pdf
Available under License : See the attached licence file.

Download (1MB) | Preview
[img]
Preview
Text (licence)
SRI_deposit_agreement.pdf
Available under License : See the attached licence file.

Download (33kB) | Preview
[img] Text
NAFLD JCEM final.docx - Accepted version Manuscript
Restricted to Repository staff only
Available under License : See the attached licence file.

Download (142kB)

Abstract

Context Randomised controlled trials in non-alcoholic fatty liver disease (NAFLD) have shown that regular exercise, even without calorie restriction, reduces liver steatosis. A previous study has shown that 16 weeks supervised exercise training in NAFLD did not affect total VLDL kinetics. Objective To determine the effect of exercise training on intrahepatocellular fat (IHCL) and the kinetics of large triglyceride-(TG)-rich VLDL1 and smaller denser VLDL2 which has a lower TG content. Design A 16 week randomised controlled trial. Patients 27 sedentary patients with NAFLD. Intervention Supervised exercise with moderate-intensity aerobic exercise or conventional lifestyle advice (control). Main outcome Very low density lipoprotein1 (VLDL1) and VLDL2-TG and apolipoproteinB (apoB) kinetics investigated using stable isotopes before and after the intervention. Results In the exercise group VO2max increased by 31±6% (mean±SEM) and IHCL decreased from 19.6% (14.8, 30.0) to 8.9% (5.4, 17.3) (median (IQR)) with no significant change in VO2max or IHCL in the control group (change between groups p<0.001 and p=0.02, respectively). Exercise training increased VLDL1-TG and apoB fractional catabolic rates, a measure of clearance, (change between groups p=0.02 and p=0.01, respectively), and VLDL1-apoB production rate (change between groups p=0.006), with no change in VLDL1 -TG production rate. Plasma TG did not change in either group. Conclusion An increased clearance of VLDL1 may contribute to the significant decrease in liver fat following 16 weeks of exercise in NAFLD. A longer duration or higher intensity exercise interventions may be needed to lower plasma TG and VLDL production rate.

Item Type: Article
Subjects : Medical Science
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
AuthorsEmailORCID
Shojaee-Moradie, FUNSPECIFIEDUNSPECIFIED
Cuthbertson, DJUNSPECIFIEDUNSPECIFIED
Barrett, MUNSPECIFIEDUNSPECIFIED
Jackson, NCUNSPECIFIEDUNSPECIFIED
Herring, RUNSPECIFIEDUNSPECIFIED
Thomas, ELUNSPECIFIEDUNSPECIFIED
Bell, JUNSPECIFIEDUNSPECIFIED
Kemp, GJUNSPECIFIEDUNSPECIFIED
Wright, JUNSPECIFIEDUNSPECIFIED
Umpleby, MUNSPECIFIEDUNSPECIFIED
Date : 1 September 2016
Identification Number : https://doi.org/10.1210/jc.2016-2353
Copyright Disclaimer : Copyright © 2016 by the Endocrine Society
Depositing User : Symplectic Elements
Date Deposited : 09 Sep 2016 07:50
Last Modified : 09 Sep 2016 07:50
URI: http://epubs.surrey.ac.uk/id/eprint/812063

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800