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Circadian dynamics in measures of cortical excitation and inhibition balance

Chellappa, SL, Gaggioni, G, Ly, JQM, Papachilleos, S, Borsu, C, Brzozowski, A, Rosanova, M, Sarasso, S, Luxen, A, Middleton, B, Archer, SN, Dijk, D, Massimini, M, Maquet, P, Phillips, C, Moran, RJ and Vandewalle, G (2016) Circadian dynamics in measures of cortical excitation and inhibition balance Scientific Reports, 6, 33661.

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Abstract

Several neuropsychiatric and neurological disorders have recently been characterized as dysfunctions arising from a ‘final common pathway’ of imbalanced excitation to inhibition within cortical networks. How the regulation of a cortical E/I ratio is affected by sleep and the circadian rhythm however, remains to be established. Here we addressed this issue through the analyses of TMS-evoked responses recorded over a 29h sleep deprivation protocol conducted in young and healthy volunteers. Spectral analyses of TMS-evoked responses in frontal cortex revealed non-linear changes in gamma band evoked oscillations, compatible with an influence of circadian timing on inhibitory interneuron activity. In silico inferences of cell-to-cell excitatory and inhibitory connectivity and GABA/Glutamate receptor time constant based on neural mass modeling within the Dynamic causal modeling framework, further suggested excitation/inhibition balance was under a strong circadian influence. These results indicate that circadian changes in EEG spectral properties, in measure of excitatory/inhibitory connectivity and in GABA/glutamate receptor function could support the maintenance of cognitive performance during a normal waking day, but also during overnight wakefulness. More generally, these findings demonstrate a slow daily regulation of cortical excitation/inhibition balance, which depends on circadian-timing and prior sleep-wake history.

Item Type: Article
Subjects : Biosciences and Medicine
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
AuthorsEmailORCID
Chellappa, SLUNSPECIFIEDUNSPECIFIED
Gaggioni, GUNSPECIFIEDUNSPECIFIED
Ly, JQMUNSPECIFIEDUNSPECIFIED
Papachilleos, SUNSPECIFIEDUNSPECIFIED
Borsu, CUNSPECIFIEDUNSPECIFIED
Brzozowski, AUNSPECIFIEDUNSPECIFIED
Rosanova, MUNSPECIFIEDUNSPECIFIED
Sarasso, SUNSPECIFIEDUNSPECIFIED
Luxen, AUNSPECIFIEDUNSPECIFIED
Middleton, BUNSPECIFIEDUNSPECIFIED
Archer, SNUNSPECIFIEDUNSPECIFIED
Dijk, DUNSPECIFIEDUNSPECIFIED
Massimini, MUNSPECIFIEDUNSPECIFIED
Maquet, PUNSPECIFIEDUNSPECIFIED
Phillips, CUNSPECIFIEDUNSPECIFIED
Moran, RJUNSPECIFIEDUNSPECIFIED
Vandewalle, GUNSPECIFIEDUNSPECIFIED
Date : 21 September 2016
Identification Number : 10.1038/srep33661
Copyright Disclaimer : © The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Uncontrolled Keywords : : Circadian, sleep, gamma, beta, theta, neural mass model
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 07 Sep 2016 10:08
Last Modified : 12 Oct 2016 14:48
URI: http://epubs.surrey.ac.uk/id/eprint/812007

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