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Selection of the appropriate method for the assessment of insulin resistance.

Borai, A, Livingstone, C, Kaddam, I and Ferns, G (2011) Selection of the appropriate method for the assessment of insulin resistance. BMC Medical Research Methodology, 11. p. 158.

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Abstract

Insulin resistance is one of the major aggravating factors for metabolic syndrome. There are many methods available for estimation of insulin resistance which range from complex techniques down to simple indices. For all methods of assessing insulin resistance it is essential that their validity and reliability is established before using them as investigations. The reference techniques of hyperinsulinaemic euglycaemic clamp and its alternative the frequently sampled intravenous glucose tolerance test are the most reliable methods available for estimating insulin resistance. However, many simple methods, from which indices can be derived, have been assessed and validated e.g. homeostasis model assessment (HOMA), quantitative insulin sensitivity check index (QUICKI). Given the increasing number of simple indices of IR it may be difficult for clinicians and researchers to select the most appropriate index for their studies. This review therefore provides guidelines and advices which must be considered before proceeding with a study.

Item Type: Article
Subjects : Medical Science
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
AuthorsEmailORCID
Borai, AUNSPECIFIEDUNSPECIFIED
Livingstone, CUNSPECIFIEDUNSPECIFIED
Kaddam, IUNSPECIFIEDUNSPECIFIED
Ferns, GUNSPECIFIEDUNSPECIFIED
Date : 23 November 2011
Identification Number : 10.1186/1471-2288-11-158
Copyright Disclaimer : © 2011 Borai et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords : Blood Glucose, Diabetes Mellitus, Type 2, Glucose Clamp Technique, Glucose Tolerance Test, Humans, Hyperinsulinism, Insulin Resistance, Metabolic Syndrome X, Reproducibility of Results, Sensitivity and Specificity
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 01 Sep 2016 13:22
Last Modified : 01 Sep 2016 13:22
URI: http://epubs.surrey.ac.uk/id/eprint/811954

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