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MicroRNA-210 and its theranostic potential

Ye, D-Q, Ren, C-X, Leng, RX, Fan, Y-G, Pan, H-F and Wu, C (2016) MicroRNA-210 and its theranostic potential Expert Opinion on Therapeutic Targets, 20 (11). pp. 1325-1338.

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MicroRNA-210 and its theranostic potential%255bPMIDA27359286%255d.pdf - Accepted version Manuscript
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Abstract

MicroRNAs (miRNAs) are a set of small single-stranded noncoding RNAs with diverse biological functions. As a prototypical hypoxamir, human microRNA-210 (hsa-miR-210) is one of the most widely studied miRNAs thus far. In addition to its involvement in sophisticated regulation of numerous biological processes, miR-210 has also been shown to be associated with the development of different human diseases including various types of cancers, cardiovascular and cerebrovascular diseases, and immunological diseases. Given its multi-faceted functions, miR-210 may serve as a novel and promising theranostic target for prevention and treatment of diseases. Areas covered: This review aims to provide a comprehensive overview of miR-210, the regulation of its expression, biological functions and molecular mechanisms, with particular emphasis on its diagnostic and therapeutic potential. Expert opinion: Although the exact roles of miR-210 in various diseases have not been fully clarified, targeting miR-210 may be a promising therapeutic strategy. Further investigations are also needed to facilitate therapeutic-clinical applications of miR-210 in human diseases.

Item Type: Article
Subjects : Biosciences and Medicine
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
AuthorsEmailORCID
Ye, D-QUNSPECIFIEDUNSPECIFIED
Ren, C-XUNSPECIFIEDUNSPECIFIED
Leng, RXUNSPECIFIEDUNSPECIFIED
Fan, Y-GUNSPECIFIEDUNSPECIFIED
Pan, H-FUNSPECIFIEDUNSPECIFIED
Wu, CUNSPECIFIEDUNSPECIFIED
Date : 12 July 2016
Identification Number : 10.1080/14728222.2016.1206890
Copyright Disclaimer : This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Opinion on Therapeutic Targets on 12 July 2016, available online: http://www.tandfonline.com/10.1080/14728222.2016.1206890
Uncontrolled Keywords : microRNA-210, Hypoxia, Biomarker, Theranostic Target
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 01 Sep 2016 12:59
Last Modified : 30 Nov 2016 17:47
URI: http://epubs.surrey.ac.uk/id/eprint/811953

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