Insulin-like growth factor-I (IGF-I) and clinical nutrition
Livingstone, C (2013) Insulin-like growth factor-I (IGF-I) and clinical nutrition Clinical Science, 125 (6). pp. 265-280.
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IGF-I (insulin-like growth factor-I) is a peptide hormone, produced predominantly by the liver in response to pituitary GH (growth hormone), which is involved in a wide variety of physiological processes. It acts in an endocrine, paracrine and autocrine manner to promote growth. The production of IGF-I signals the availability of nutrients needed for its anabolic actions. Recently, there has been growing interest in its role in health and disease. IGF-I has long been known to be regulated by nutrition and dysregulated in states of under- and over-nutrition, its serum concentrations falling in malnutrition and responding promptly to refeeding. This has led to interest in its utility as a nutritional biomarker. A considerable evidence base supports utility for measurement of IGF-I in nutritional contexts. Its concentration may be valuable in providing information on nutritional status, prognosis and in monitoring nutritional support. However, it is insufficiently specific for use as a screening test for under nutrition as its serum concentration is influenced by many factors other than nutritional status, notably the APR (acute-phase response) and endocrine conditions. Concentrations should be interpreted along with clinical findings and the results of other investigations such as CRP (C-reactive protein). More recently, there has been interest in free IGF-I which holds promise as a nutritional marker. The present review covers nutritional regulation of IGF-I and its dysregulation in disease, then goes on to review recent studies supporting its utility as a nutritional marker in clinical contexts. Although not currently recommended by clinical guidelines, it is likely that, in time, measurement of IGF-I will become a routine part of nutritional assessment in a number of these contexts.
|Subjects :||Medical Science|
|Divisions :||Faculty of Health and Medical Sciences > School of Biosciences and Medicine|
|Date :||1 September 2013|
|Identification Number :||10.1042/CS20120663|
|Copyright Disclaimer :||© The Authors Journal compilation © 2013 Biochemical Society|
|Depositing User :||Symplectic Elements|
|Date Deposited :||01 Sep 2016 11:25|
|Last Modified :||01 Sep 2016 11:25|
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