Insulin-like growth factor-II: its role in metabolic and endocrine disease.
Livingstone, C and Borai, A (2014) Insulin-like growth factor-II: its role in metabolic and endocrine disease. Clinical Endocrinology, 80 (6). pp. 773-781.
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Insulin-like growth factor-II (IGF-II) is a widely expressed 7·5 kDa mitogenic peptide hormone. Although it is abundant in serum, understanding of its physiological role is limited compared with that of IGF-I. IGF-II regulates foetal development and differentiation, but its role in adults is less well understood. Evidence suggests roles in a number of tissues including skeletal muscle, adipose tissue, bone and ovary. Altered IGF-II expression has been observed in metabolic conditions, notably obesity, diabetes and the polycystic ovary syndrome. This article summarizes what is known about the actions of IGF-II and its dysregulation in metabolic and endocrine diseases. The possible causes and consequences of dysregulation are discussed along with the implications for diagnostic tests and future research.
|Subjects :||Medical Science|
|Divisions :||Faculty of Health and Medical Sciences > School of Biosciences and Medicine|
|Date :||June 2014|
|Identification Number :||10.1111/cen.12446|
|Copyright Disclaimer :||© 2014 John Wiley & Sons Ltd|
|Uncontrolled Keywords :||Animals, Bone Diseases, Metabolic, Diabetes Mellitus, Endocrine System, Endocrine System Diseases, Female, Gene Expression Regulation, Growth Disorders, Humans, Insulin-Like Growth Factor I, Insulin-Like Growth Factor II, Male, Metabolic Diseases, Mice, Obesity, Polycystic Ovary Syndrome|
|Related URLs :|
|Depositing User :||Symplectic Elements|
|Date Deposited :||01 Sep 2016 07:47|
|Last Modified :||01 Sep 2016 07:47|
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