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Distribution and load of elephant endotheliotropic herpesviruses in tissues from associated fatalities of Asian elephants

Seilern-Moy, K, Darpel, KE, Steinbach, F and Dastjerdi, A (2016) Distribution and load of elephant endotheliotropic herpesviruses in tissues from associated fatalities of Asian elephants Virus Research, 220. pp. 91-96.

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Abstract

Elephant Endotheliotropic Herpesviruses (EEHVs) are the cause of a highly fatal haemorrhagic disease in elephants primarily affecting young Asian elephants (Elephas maximus) in both captivity and in the wild. The viruses have emerged as a significant threat to Asian elephant conservation, critically affecting overall sustainability of their population. So far insight into the pathogenesis of EEHV infections has been restricted to examination of EEHV-infected tissues. However, little is known about distribution and burden of the viruses within the organs of fatal cases, crucial elements in the understanding of the virus pathogenesis. This study was therefore undertaken to assess the extent of organ and cell involvement in fatal cases of EEHV-1A, 1B and 5 using a quantitative real-time PCR. EEHV-1 and 5 DNA were detectable in all the tissues examined, albeit with substantial differences in the viral DNA load. The highest EEHV-1A DNA load was observed in the liver, followed by the heart, thymus and tongue. EEHV-1B and 5 showed the highest DNA load in the heart, followed by tongue and liver. This study provides new insights into EEHV pathogenicity and has implications in choice of sample type for disease investigation and virus isolation.

Item Type: Article
Subjects : Veterinary Medicine
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
AuthorsEmailORCID
Seilern-Moy, KUNSPECIFIEDUNSPECIFIED
Darpel, KEUNSPECIFIEDUNSPECIFIED
Steinbach, FUNSPECIFIEDUNSPECIFIED
Dastjerdi, AUNSPECIFIEDUNSPECIFIED
Date : 19 April 2016
Identification Number : 10.1016/j.virusres.2016.04.012
Copyright Disclaimer : © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Depositing User : Symplectic Elements
Date Deposited : 31 Aug 2016 17:41
Last Modified : 31 Aug 2016 17:41
URI: http://epubs.surrey.ac.uk/id/eprint/811937

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