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Applying proteomics to study crosstalk at the cartilage-subchondral bone interface in osteoarthritis: current status and future directions

Fellows, CR, Matta, C and Mobasheri, A (2016) Applying proteomics to study crosstalk at the cartilage-subchondral bone interface in osteoarthritis: current status and future directions EBioMedicine., 11. pp. 2-4.

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Abstract

Osteoarthritis (OA) is the most common age-related degenerative joint disorder. It is considered a disease of the entire joint, which is not simply a result of attrition but rather abnormal remodelling and coalescent failure of multiple tissues. Despite the prevalence of OA, therapeutic strategies are currently limited to the treatment of pain and inflammation. New disease-modifying agents that slow progression and diagnostic biomarkers are urgently required. Given the lack of treatment options to repair degradation of articular cartilage, anti-resorptive agents and anabolics, such as bisphosphonates, are candidate treatments for OA (Karsdal et al., 2014). An optimal treatment for OA will likely target at least two joint tissues, yet the factors that govern the bone-cartilage interactions during pathogenesis remain largely unknown.

Item Type: Article
Subjects : Veterinary Medicine
Divisions : Faculty of Health and Medical Sciences > School of Veterinary Medicine
Authors :
AuthorsEmailORCID
Fellows, CRUNSPECIFIEDUNSPECIFIED
Matta, CUNSPECIFIEDUNSPECIFIED
Mobasheri, AUNSPECIFIEDUNSPECIFIED
Date : 3 September 2016
Identification Number : 10.1016/j.ebiom.2016.08.047
Copyright Disclaimer : © 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 31 Aug 2016 10:38
Last Modified : 30 Nov 2016 15:02
URI: http://epubs.surrey.ac.uk/id/eprint/811922

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