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Changes in metabolic indices in response to whole blood donation in male subjects with normal glucose tolerance

Borai, A, Livingstone, C, Farzal, A, Baljoon, D, Al Sofyani, A, Bahijri, S, Kadam, I, Hafiz, K, Abdelaal, M and Ferns, G (2015) Changes in metabolic indices in response to whole blood donation in male subjects with normal glucose tolerance CLINICAL BIOCHEMISTRY, 49 (1-2). pp. 51-56.

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Abstract

Objectives Previous studies have investigated the impact of venesection upon different metabolic indices in patients with various conditions (e.g., type 2 diabetes and iron overload). We aimed to investigate the changes on different metabolic indices including glycemic, iron, lipids and inflammatory markers at different time points after blood donation in male subjects with normal glucose tolerance.Design and methods 42 male subjects were recruited to the study. Glucose tolerance was assessed by oral glucose tolerance test before (visit A) and after the blood donation (1 day, visit B; 1 week, visit C; 3 weeks, visit D; and 3 months, visit E). Fasting glucose, HbA1c, insulin, lipids, uric acid, C-reactive protein, iron stores and insulin resistance (HOMA-IR, ISI-gly) indices were measured. A repeated measures ANOVA was used for comparisons of quantitative variables between different visits. Results All subjects had normal glucose tolerance according to WHO criteria. Fasting glucose, insulin and HOMA-IR were significantly higher (~ 2%, p < 0.05; ~ 21%, p < 0.01; and ~ 11%, p < 0.05 respectively) at visit B following donation. At visit D, the mean ± SE for HbA1c (5.28 ± 0.06%) was significantly lower with a difference in percentage of ~− 3% and p < 0.05 compared to visit A (5.44 ± 0.06%). Ferritin decreased significantly at visits B, C, D and E (~− 8%, p < 0.01, ~− 24%, p < 0.001, ~− 39%, p < 0.001 and ~− 29%, p < 0.01 respectively), when compared to visit A. Conclusions At different time points after blood donation, glycemic status and iron stores are affected significantly in male blood donors with normal glucose tolerance. The changes were particularly evident three weeks after donation. Hence, the interpretation of these parameters in male blood donors needs to take this into account, and the mechanisms resulting in these effects need to be clarified.

Item Type: Article
Subjects : Biosciences and Medicine
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
AuthorsEmailORCID
Borai, AUNSPECIFIEDUNSPECIFIED
Livingstone, CUNSPECIFIEDUNSPECIFIED
Farzal, AUNSPECIFIEDUNSPECIFIED
Baljoon, DUNSPECIFIEDUNSPECIFIED
Al Sofyani, AUNSPECIFIEDUNSPECIFIED
Bahijri, SUNSPECIFIEDUNSPECIFIED
Kadam, IUNSPECIFIEDUNSPECIFIED
Hafiz, KUNSPECIFIEDUNSPECIFIED
Abdelaal, MUNSPECIFIEDUNSPECIFIED
Ferns, GUNSPECIFIEDUNSPECIFIED
Date : 28 August 2015
Identification Number : 10.1016/j.clinbiochem.2015.08.023
Copyright Disclaimer : © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords : Science & Technology, Life Sciences & Biomedicine, Medical Laboratory Technology, Hb1Ac, Iron, Insulin resistance, Blood donation, HOMA-IR, Venesection, BETA-CELL FUNCTION, INSULIN SENSITIVITY, MYOCARDIAL-INFARCTION, BIOLOGICAL VARIATION, OXIDATIVE STRESS, PLASMA-GLUCOSE, HEART-DISEASE, IRON STORES, RESISTANCE, COMPLICATIONS
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 09 Aug 2016 14:53
Last Modified : 09 Aug 2016 14:53
URI: http://epubs.surrey.ac.uk/id/eprint/811646

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